Genome-Wide Identification and In Silico Expression Analysis of Gene Family in (Citrus) in Response to Abiotic Stress.

The (citrus) plant produces various phytohormones due to the significant involvement of the carotenoid cleavage oxygenase () gene family in its growth and development. genes can be divided into two main categories: (9-cis-epoxy carotenoid dioxygenase), responsible for abscisic acid (ABA) production, and (carotenoid cleavage dioxygenase), involved in pigment and strigolactone formation. To better understand the roles and positions of gene members in relation to these hormones, researchers analyzed the clementine genome.

Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties.

Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with species and is associated with an inflammatory response and nociception. The available treatments against leishmaniasis are inadequate, as they are associated with high cost, toxicity, and increased resistance.

Teachers' academic motivation and student procrastination behaviour: mediating effects of emotion regulation and study habits.

Purpose: The present study aimed to analyze the effectiveness of external and personal regulatory mechanisms in reducing procrastination behavior among university students. For this purpose, the role of teachers' academic motivation is worthwhile in shaping the learning environment and reducing procrastination, with a focus on the mediating roles of emotion regulation and study habits considered imperative.

Research Design/method: By employing a quantitative, cross-sectional research design, data were collected from a sample of 210 teachers working in universities located in Multan-Pakistan via convenient sampling, yielding a usable response rate of 70.

Morphological Features Influence the Drug Loading and Delivery Efficacy of Photoactivatable Gold Nanocarriers for Antitumor Photo/Chemotherapy.

Photoactivatable gold nanocarriers are transforming antitumor therapies by leveraging their distinctive physicochemical properties, enabling targeted drug delivery and enhanced therapeutic efficacy in cancer treatment. This study systematically investigates how surface topography and morphology of gold nanocarriers influence drug loading capacity, light-to-heat conversion efficiency, and overall therapeutic performance in photo/chemotherapy. We synthesized four distinct morphologies of gold nanoparticles: porous gold nanocups (PAuNCs), porous gold nanospheres (PAuNSs), solid gold nanocups (SAuNCs), and solid gold nanospheres (SAuNSs).

Level of cognitive functioning among elderly patients in urban area of Bangladesh: A cross-sectional study.

Bangladesh is experiencing rapid urbanization and a growing elderly population, particularly in urban areas. Cognitive decline, ranging from mild cognitive impairment to dementia, is a prevalent issue among elderly populations globally. Understanding the current state of cognitive functioning in this demographic is essential for informing effective healthcare plans and programs.

Delayed postoperative impedance issues in patients treated with deep brain stimulation: A single-center retrospective study.

Background: In rare circumstances, an implanted deep brain stimulation device will develop impedance issues across its contacts. Even more rare is the resultant inability to program a patient effectively, or that the patients' prior programming settings become unusable.

Objective: In this study we investigate this occurrence across the device manufacturers implanted, and whether this could be resolved.

Clinical course and outcome of adult patients with primary focal segmental glomerulosclerosis with kidney function loss on presentation.

Background: Kidney function loss or renal insufficiency indicated by elevated creatinine levels and/or an estimated glomerular filtration rate (eGFR) < 60 mL/minute/1.73 m² at presentation in patients with primary focal segmental glomerulosclerosis (FSGS) is commonly seen as a poor prognostic marker for kidney survival. However, a pre>vious study from our center suggested this may be due to hemodynamic factors.

Aortic Dissection Complicated by Mesenteric Malperfusion Syndrome Presenting As Hepatic Ischemia: A Case Report and Literature Review.

Aortic dissection (AD) is a medical emergency that occurs as a result of a compromise in the structural integrity of the aorta. If left untreated, AD can have severe consequences such as organ dysfunction or even death. Malperfusion syndrome is a major complication of aortic dissection with mesenteric malperfusion syndrome being a rare but devastating form that can lead to mesenteric ischemia and is associated with poor prognosis despite timely management.

Obliged to fight? Patient moral processes in the face of poor prognosis cancer.

Objective: Theoretical work suggests that moral psychological processes-those pertaining to the interests or welfare of others-are a key driver of overtreatment at the end of life. We examined patient moral processes and their associations with distress and treatment decision-making.

Method: During structured interviews with 116 patients with advanced cancer and a poor prognosis, Likert scale items were used to operationalize (a) moral emotions: feeling shame and guilt about cancer getting worse, (b) moral motives for cancer treatment: perceiving an obligation to family for continuing potentially nonbeneficial treatments, and (c) moral performance: putting up the appearance of feeling better than how one is really feeling (5-point response scale, ).

Associations Between Adolescent Food Environments and Dietary Intake.

Objective: To examine aspects of the home and neighborhood food environment as predictors of adolescent diet.

Design: Cross-sectional study.

Setting: Research laboratory in Nebraska.

Pyrazolone-nicotinic acid derivative (4Z)-4-(2-hydroxybenzylidine)-5-methyl-2-(pyridine-3-ylcarbonyl)-2, 4-dihydro-3H-pyrazole-3-one (IIc) as multitarget inhibitor of neurodegeneration and behavioural impairment in Dementia.

Objective: The study was aimed at the synthesis and pharmacological investigation of (4Z)-4-(2-hydroxybenzylidine)-5-methyl-2-(pyridine-3-ylcarbonyl)-2, 4-dihydro-3H-pyrazole-3-one (IIc) in mice model of scopolamine-induced neurodegeneration and cognition impairment.

Methods: The behavioural studies included Y-Maze Test, Water Morris Test, and Novel Object Recognition Test in Albino mice (20-25 g). Scopalamine was used as an inducing agent.

Impact of heavy metals, oxidative stress, expression of VHL, and antioxidant genes in the pathogenesis of renal cell carcinoma.

Introduction: Heavy metals exposure is a known carcinogen in humans. The impact of heavy metals in the pathogenesis of renal cell carcinoma (RCC) is unclear with scant available literature. Though previous studies have evaluated the role of heavy metals in RCC, majority of those studies have evaluated either single or few heavy metals in urine.

Ultrafast microwave synthesis of MoSSe@ graphene composites via dual anion design for long-cyclable Li-S batteries.

Lithium-sulfur batteries (LSBs) have been increasingly recognized as a promising candidate for the next-generation energy-storage systems. This is primarily because LSBs demonstrate an unparalleled theoretical capacity and energy density far exceeding conventional lithium-ion batteries. However, the sluggish redox kinetics and formidable dissolution of polysulfides lead to poor sulfur utilization, serious polarization issues, and cyclic instability.

A Rare Case of Severe Folate Deficiency-Induced Pancytopenia.

Chronic alcoholism is a well-documented cause of folate deficiency, with past studies revealing high prevalence rates among alcoholics. Despite mandatory folate fortification in the UK from 2021, individuals with chronic alcohol consumption remain susceptible to severe folate deficiencies. This case study explores the hematological impact of severe folate deficiency in a 38-year-old female chronic alcoholic who presented with pancytopenia.

Sources and types of plastic caps and properties characterization of plastic ropes produced from different types of plastic caps.

Bangladesh produces massive amounts of plastic products to meet the huge population demand. Jashore (Bangladesh) is well-known for discarding huge numbers of plastic caps (PCs). PCs are made up of hard polymer of polypropylene (PP) and high-density polyethylene (HDPE).

Overcoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer.

Prostate cancer (PCa) is the second leading cause of cancer-related death in American men. PCa that relapses after hormonal therapies, referred to as castration resistant PCa (CRPC), often presents with metastases (mCRPC) that are the major cause of mortality. The few available therapies for mCRPC patients include taxanes docetaxel (DTX) and cabazitaxel (CBZ).

Relevance of fintech and energy transition to green growth: Empirical evidence from China.

Due to its heavy reliance on fossil fuels and rapid urbanization, China's economic growth is accompanied by environmental problems. Hence, it is vital to solve the issue by promoting green growth and finding factors to boost it. The current study presents FinTech as a factor enhancing green growth in China through the mediation effect of the energy transition.

Repercussions of Pakistan's renewable and non-renewable energies to the environmental footprint: Applying the non-linear ARDL estimation.

The energy consumption in Pakistan, both renewable and nonrenewable, is examined herein as an important factor in carbon emissions. Employing a nonlinear ARDL (auto-regressive distributed lag), the research examines data from 1980 to 2021. The results show that the use of renewable energy has a negligible effect when it comes to the nation's overall carbon emissions.

Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells.

Isatin, a heterocycle scaffold, is the backbone of many anticancer drugs and has previously been reported to engage multiple cellular targets and mechanisms, including angiogenesis, cell cycle, checkpoint pathways and multiple kinases. Here, we report that a novel isatin derivative, 5i, degrades estrogen receptor alpha (ERα) in estrogen-dependent breast cancer cells. This effect of the isatin nucleus has not been previously reported.

Adverse events associated with chimeric antigen receptor T-cell therapy in ophthalmology: a narrative review.

Chimeric antigen receptors are synthetically produced receptors engineered to engage with target cells with high specificity. These cells are created by inserting an artificial T-cell receptor into an immunoglobulin's antigen-binding region, allowing the cells to combine and target specific antigens. The use of chimeric antigen receptor (CAR) T-cell therapy has been a remarkable achievement in the field of immunotherapy, particularly in the treatment of ophthalmic tumors like retinoblastoma and uveal melanoma.