Anaplasma marginale Outer Membrane Protein A Is an Adhesin That Recognizes Sialylated and Fucosylated Glycans and Functionally Depends on an Essential Binding Domain.

causes bovine anaplasmosis, a debilitating and potentially fatal tick-borne infection of cattle. Because is an obligate intracellular organism, its adhesins that mediate entry into host cells are essential for survival. Here, we demonstrate that outer membrane protein A (AmOmpA; AM854) contributes to the invasion of mammalian and tick host cells.