Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from SAFER-Study.

Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough COVID-19 occurring in IMRD patients participating in the SAFER-study, a Brazilian multicentric cohort evaluating the safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines in patients with autoimmune diseases.

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer.

Background: Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA.

Flexural properties and fatigue limit of 3D-printed and milled resin-based materials.

Purpose: The purpose of this study was to evaluate the flexural strength (FS), flexural modulus (FM), and fatigue limit (FL) of 3D-printed resin-based polymers and composites and compare them to 3D-printed composites.

Materials And Methods: A bar-shaped specimen (25 × 2 × 2 mm) was CAD designed according to ISO 4049:2019, and 60 duplicates of the 3D model were nested at a 45-degree angle with the printing platform and 3D-printed with three materials: denture teeth resin (Denture Teeth, Formlabs), temporary crown and bridge resin (Temporary CB, Formlabs), and composite (Flexcera Smile Ultra+, Desktop Health). The 3D model was also imported into a dental CAM software, duplicated 60 times, nested, and milled from a 3D-milled composite puck (Ivotion Denture Teeth, Ivoclar).

Challenges in the Management of Psoriatic Arthritis in Latin America: A Systematic Review.

Purpose: In 2020, the International League of Associations for Rheumatology published recommendations for managing psoriatic arthritis (PsA), aiming to adapt the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis and the European Alliance of Associations for Rheumatology recommendations to low-income countries. At that time, the paucity of clinical studies examining the management of patients with PsA in Latin America was remarked on by the international working group. Therefore, the primary objective of this systematic literature review was to investigate the main challenges in managing PsA in Latin America as described in recent publications.

Digitally designed and additively manufactured tooth reduction guides for porcelain laminate veneer preparations: A clinical report.

Porcelain laminate veneers are a conservative treatment to enhance esthetics, tooth shape, color, and contours. Enamel preservation during tooth preparation is essential for the long-term success of these micromechanically retained partial coverage restorations. Different methods have been described to clinically assess tooth preparation relative to definitive restorative contours.

Effect of cannabidiol oil on the color stability of resin composites.

Purpose: To evaluate the influence of cannabidiol (CBD) oil on the color stability of resin composites.

Methods: Three different resin composites were chosen to prepare 90 disk-shaped specimens. The specimens were randomly selected to compose two test groups (classic CBD or chocolate CBD) and one control group (distilled water) for a 14-day test.

Improved estimation in negative binomial regression.

Negative binomial regression is commonly employed to analyze overdispersed count data. With small to moderate sample sizes, the maximum likelihood estimator of the dispersion parameter may be subject to a significant bias, that in turn affects inference on mean parameters. This article proposes inference for negative binomial regression based on adjustments of the score function aimed at mean or median bias reduction.

Bioactive Dental Adhesive System With -Farnesol: Effects on Dental Biofilm and Bonding Properties.

Background: Composite dental restorations are commonly used to restore cavitated carious lesions. Unfortunately, the main reason for failure is the development of secondary caries adjacent to the restoration. To improve the long-term survival of restorations, antibacterial agents have been added into dental materials.

Incidence of tuberculosis in patients receiving anti-TNF therapy for rheumatic diseases: a systematic review.

Introduction: The TNF inhibitors were the first immunobiologicals used to treat rheumatic diseases, but their use is associated with an increased risk of tuberculosis. The primary objective is to estimate the incidence of tuberculosis in patients with rheumatic diseases exposed to anti-TNF therapy. The secondary objectives are to evaluate the incidence of tuberculosis by region and subgroups of diseases, to review the presentation of tuberculosis in these patients, and to assess the time elapsed between onset of anti-TNF therapy and development of active granulomatous disease.

A population-based study of tuberculosis incidence among rheumatic disease patients under anti-TNF treatment.

Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. The advent of immunobiologic therapy with TNF inhibitors agents, has been associated with a significant increase in incident cases of tuberculosis in this population.

Objective: To estimate the incidence of tuberculosis in patients receiving TNF inhibitors therapy for rheumatic diseases.

Effects of Light Attenuation through Dental Tissues on Cure Depth of Composite Resins.

Objective: Polymerization of light-cured resin-based materials is well documented; however, the intensity of the activating light can be reduced by passage through air, dental structure, or restoration compromising the physical properties of the restoration. The aim of this study was to evaluate the depth of cure of different light cured composite resins polymerized directly or transdental, through enamel and enamel/dentin tissues.

Material And Methods: Five composite resins were selected for this experiment: SureFil SDR, Dentsply (SDR), Filtek Supreme Plus, 3M ESPE (FSP), Aelite LS, Bisco (ALS), Filtek LS, 3M ESPE (FLS), and TPH, Dentsply (TPH).

Median bias reduction in random-effects meta-analysis and meta-regression.

The reduction of the mean or median bias of the maximum likelihood estimator in regular parametric models can be achieved through the additive adjustment of the score equations. In this paper, we derive the adjusted score equations for median bias reduction in random-effects meta-analysis and meta-regression models and derive efficient estimation algorithms. The median bias-reducing adjusted score functions are found to be the derivatives of a penalised likelihood.

Substantivity of Carbodiimide Inhibition on Dentinal Enzyme Activity over Time.

The use of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl (EDC) has recently been investigated for its effectiveness in the prevention of collagen degradation over time and the improvement of resin-dentin bond durability. The objective of the present study was to evaluate the effects of a 0.3 M EDC-containing conditioner on endogenous enzymatic activities within the hybrid layer (HL) created by a self-etch or an etch-and-rinse adhesive after 1 y.

A composite likelihood approach to predict the sex of the baby.

Couples with diseases associated with the sexual chromosomes, as well as families in countries where the desire for a male is extreme, are interested in influencing the sex of the baby. We propose an original composite likelihood approach to analyse the relation between sex of the newborn and timing of the intercourse which leads to conception. Although there exist numerous works on this relation, only few studies have been carried out on independent datasets to validate the existing theories.

The influence of intrinsic water permeation on different dentin bonded interfaces formation.

Objectives: To determine the effects of intrinsic wetness on the formation of dentin bonding interfaces of four resin cement systems bonded to dentin under different pulpal pressures.

Methods: Thirty-six freshly extracted third molars were selected and processed for dentin μTBS. The teeth were randomly assigned into 12 experimental groups, according to the adhesive luting system [Adper Single Bond Plus (3M ESPE) combined with two luting agents RelyX ARC (3M ESPE) and heated Filtek Z250 Universal Restorative (3M ESPE), Clearfil CD Bond (Kuraray) combined with Clearfil Esthetic Cement (Kuraray), and RelyX Unicem 2 Automix (3M ESPE)] and pulpal pressure (0, 5, and 20 cm of simulated pulpal pressure).

Application of 17% EDTA Enhances Diffusion of (45)Ca-labeled OH(-) and Ca(2+) in Primary Tooth Root Canal.

Proper cleaning of the root canal is key to the success of endodontic treatment as it allows more effective diffusion of medication throughout the dentinal tubules. The aim of this in vitro study was to investigate the efficacy of 17% ethylenediaminetetraacetic acid (EDTA) in enhancing diffusion of hydroxyl (OH(-)) and calcium ions (Ca(2+)) throughout the root canal in primary teeth. The canals of 25 primary tooth roots were cleaned with endodontic files and 1% sodium hypochlorite.

Permeation of intrinsic water into ethanol- and water-saturated, monomer-infiltrated dentin bond interfaces.

Objectives: The aim of this study was to evaluate the formation of dentin bonding interfaces using the water-wet and the ethanol-wet techniques under simulated pulpal pressure, and to assess the effect of adhesive solvent and thermomechanical loading.

Methods: Flat dentin surfaces were restored under 20mm-simulated pulpal pressure following two bonding approaches (water-wet and ethanol-wet bonding) in combination with dental adhesives containing ethanol (Single Bond Plus and Scotchbond Multi-Purpose) or acetone (One-Step Plus and All-Bond 2) as solvent. Half of the restorations of each subgroup were subjected to thermocycling followed by cyclic loading (three teeth per group).

Integrated likelihoods in parametric survival models for highly clustered censored data.

In studies that involve censored time-to-event data, stratification is frequently encountered due to different reasons, such as stratified sampling or model adjustment due to violation of model assumptions. Often, the main interest is not in the clustering variables, and the cluster-related parameters are treated as nuisance. When inference is about a parameter of interest in presence of many nuisance parameters, standard likelihood methods often perform very poorly and may lead to severe bias.

Color stability of shade guides after autoclave sterilization.

This study evaluated the influence of 120 autoclave sterilization cycles on the color stability of two commercial shade guides (Vita Classical and Vita System 3D-Master). The specimens were evaluated by spectrophotometer before and after the sterilization cycles. The color was described using the three-dimensional CIELab system.

Dental floss selection and its impact on evaluation of interproximal contacts in licensure exams.

Ideal interproximal contacts between adjacent natural teeth or dental restorations are a critical factor for the health of the dental-alveolar complex. Interproximal contact tightness is a physiological entity affected by many patient-related and restorative parameters. This variation poses a challenge in defining the "clinically acceptable" contact area tightness (CAT) and therefore how students and clinicians should be trained to evaluate this parameter.

The influence of desensitizing dentifrices on pain induced by in-office bleaching.

The purpose of this study was to evaluate whether the use of desensitizing dentifrices used 15 days prior to and after in-office tooth bleaching could eliminate or reduce tooth sensitivity. After institutional review board approval and informed consent, 45 subjects were selected and divided into 3 groups according to the dentifrice selected: Colgate Total (CT), Colgate Sensitive Pro-Relief (CS) or Sensodyne ProNamel (SP). The subjects used toothpaste and a toothbrush provided to them for 15 days prior to bleaching.

Influence of chlorhexidine digluconate on the clinical performance of adhesive restorations: a 3-year follow-up.

Objectives: The aim of this clinical study was to evaluate the long-term clinical performance of non-carious Class V restorations with and without application of chlorhexidine digluconate to acid-etched dentine.

Methods: After the approval of the Ethics and Informed Consent Committee, 70 non-carious cervical lesions were selected and randomly assigned into two groups, according to the split mouth design. The control group was restored with a two-step etch-and-rinse adhesive (Adper Single Bond 2) following manufacturer's instructions; whereas in the experimental group 2% chlorhexidine digluconate solution was applied to acid etched dentine for 30s after etching and prior to the adhesive application.

Time trends in the treatment and prognosis of resectable pancreatic cancer in a large tertiary referral centre.

Objectives: Mortality in pancreatic cancer has remained unchanged over the last 20-30 years. The aim of the present study was to analyse survival trends in a selected population of patients submitted to resection for pancreatic cancer at a single institution.

Methods: Included were 544 patients who underwent pancreatectomy for pancreatic cancer between 1990 and 2009.

Detection of microRNAs in archival cytology urine smears.

MicroRNAs' dysregulation and profiling have been demonstrated to be clinically relevant in urothelial carcinoma (UC). Urine cytology is commonly used as the mainstay non-invasive test for secondary prevention and follow-up of UC patients. Ancillary tools are needed to support cytopathologists in the diagnosis of low-grade UC.