Publications by authors named "Sarter H"
Article Synopsis
- The incidence of inflammatory bowel disease (IBD) in Northern France was studied over a 30-year period, revealing 22,879 new cases, with Crohn's disease (CD) and ulcerative colitis (UC) making up the majority.
- The incidence rates for both CD and UC increased significantly over the years, particularly in children and young adults, indicating a rising trend in these demographics.
- The findings suggest ongoing environmental factors contributing to the increasing prevalence of IBD, especially among women with UC, with projections indicating that nearly 0.6% of the population will have IBD by 2030.
Purpose: This study aimed to document utility values and the Visual Analog Scale (VAS) with the 5-level version of the EQ-5D questionnaire in a large sample of patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
Methods: QALY-MICI was a cross-sectional survey across three sources in France. Data were collected between 2019 and 2022 for patients 18 and over.
Article Synopsis
- Patients with inflammatory bowel disease (IBD), specifically children with Crohn's disease (CD) and ulcerative colitis (UC), have a higher risk of thromboembolic events (TE), but more information is needed regarding the incidence and risk factors for better preventative care.
- The study followed 1,344 pediatric patients from 1988 to 2013, finding very few instances of arterial (ATE) and venous thromboembolic events (VTE) during the follow-up period, with VTE being more frequent in specific circumstances.
- Overall, while the risk of TE in this population is low, it was significantly linked to periods of active disease, post-surgery conditions, and hospitalization, while treatment with
Background: The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn's disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD.
Methods: Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry.
Introduction: We evaluated the impact of immunosuppressants (IS) and antitumor necrosis factor (TNF) introduction on long-term outcomes of ulcerative colitis (UC) in a large population-based pediatric-onset cohort.
Methods: All patients included in the EPIMAD registry with a diagnosis of UC made before the age of 17 years between 1988 and 2011 were followed up retrospectively until 2013. Medication exposure and disease outcomes were compared between 3 diagnostic periods: 1988 to 1993 (period [P] 1; pre-IS era), 1994 to 2000 (P2; pre-anti-TNF era), and 2001 to 2011 (P3; anti-TNF era).
Article Synopsis
- Anti-TNF agents, commonly used to treat inflammatory bowel disease in patients diagnosed before age 17, show varied long-term effectiveness, especially in pediatric cases.
- A study of 1,007 Crohn's disease patients and 337 ulcerative colitis patients revealed significant failure rates for first-line anti-TNF therapy, with risks higher in the first year and female patients having increased rates of loss of response and intolerance.
- Despite 13.5% experiencing adverse events leading to treatment cessation, there were no deaths or serious conditions like cancer reported during anti-TNF therapy.
Article Synopsis
- Anal ulcerations are common in pediatric patients with Crohn's disease, with 25.6% experiencing them at diagnosis, and the 5 and 10-year cumulative incidence being 38.4% and 44.0%, respectively.
- Extraintestinal symptoms and locations of Crohn's disease in the upper digestive tract increase the risk of developing anal ulcerations, while ileal locations reduce that risk.
- A history of anal ulceration significantly raises the likelihood of developing fistulizing perianal Crohn's disease, with 23.3% of patients experiencing this after several years of follow-up.
Background And Aims: Paediatric-onset IBD [pIBD] is associated with an increased risk of cancer and mortality in adulthood. The aims of this study were to measure the incidence of cancer and mortality in patients with pIBD and identify factors associated with mortality and cancer.
Methods: All patients diagnosed with Crohn's disease [CD] or ulcerative colitis [UC] before the age of 17 years between 1988 and 2011 in the EPIMAD registry were retrospectively followed until 2013 for cancer and 2015 for mortality.
Background & Aims: We evaluated the impact of immunosuppressants (IS) and anti-tumor necrosis factor (TNF) introduction on Crohn's disease (CD) long-term outcomes in a large population-based, pediatric-onset cohort.
Methods: All patients included in the EPIMAD registry with a diagnosis of CD occurring when they were younger than age 17 years and between 1988 and 2011 were followed up retrospectively until 2013. Three diagnostic periods were defined: 1988 to 1993 (period [P]1; pre-IS era), 1994 to 2000 (P2; pre-anti-TNF era), and 2001 to 2011 (P3; anti-TNF era).
Background And Aims: This study prompted by growing evidence of the relationship between the yeast and Crohn's disease (CD) was intended to assess the effect of a 6-month course of the antifungal fluconazole (FCZ) on post-operative recurrence of CD.
Methods: Mycological samples (mouth swabs and stools) and serum samples were collected from 28 CD patients randomized to receive either FCZ ( = 14) or placebo ( = 14) before surgical resection. Serological analysis focused on levels of calprotectin, anti-glycan antibodies, and antibody markers of pathogenic transition.
Introduction: Most studies of elderly-onset Crohn's disease [CD; diagnosed in patients aged 60 or over] have described a mild course. However, data on the natural history of perianal fistulising CD [pfCD] in this population are scarce. In a population-based cohort study, we described the prevalence, natural history, and treatment of pfCD in patients with elderly-onset CD vs patients with paediatric-onset CD.
View Article and Find Full Text PDFBackground: Geographical variations in Crohn's disease (CD) suggest that the environment has a role in the pathogenesis of this condition.
Aims: To describe the spatial distribution and the clustering of CD cases in France, and to assess the relationship between the prevalence of CD and environmental risk factors.
Methods: We identified all patients with CD included in the French hospital discharge database from 2007 to 2014.
Long-Term Natural History of Microscopic Colitis: A Population-Based Cohort.
Clin Transl Gastroenterol
September 2019
Objectives: Data on long-term natural history of microscopic colitis (MC), including collagenous (CC) and lymphocytic colitis (LC), are lacking.
Methods: All new cases of MC diagnosed in the Somme area, France, between January 1, 2005, and December 31, 2007, were prospectively included. Colonic biopsies from all patients were reviewed by a group of 4 gastrointestinal pathologist experts to assess the diagnosis of CC or LC.
Background: Pediatric-onset Crohn's disease (CD) may represent a more severe form of disease. The aim of this study was to describe long-term outcome and identify associated risk factors of complicated behavior in a large population-based pediatric-onset CD cohort.
Patients And Methods: Cases included all patients recorded in the EPIMAD registry diagnosed with definite or probable CD between January 1988 and December 2004, under the age of 17 years at the time of diagnosis, with at least two years of follow-up.
Background: Extraintestinal manifestations (EIM) have been associated with more severe course of inflammatory bowel disease. The aim was to study the frequency of EIM in pediatric- and elderly-onset Crohn's disease (CD) and the factors associated with EIM and their impact on long-term disease outcome.
Methods: Pediatric- (age at diagnosis younger than 17 years) and elderly-onset CD patients (age at diagnosis 60 years or older) from a prospective population-based registry (EPIMAD) were recruited.
Background: Recent population-based study of elderly-onset Crohn's disease patients reported age-related differences in disease phenotype and outcome.
Aims: The aim was to assess the impact of age at diagnosis on natural history of elderly-onset ulcerative colitis patients with emphasis on disease presentation, phenotype and treatment.
Methods: Elderly-onset patients with ulcerative colitis (≥60 years at diagnosis) registered in a French population-based Registry EPIMAD (1988-2006) were included.
Background: IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce.
Aim: To describe the incidence of and factors associated with post-operative complications in elderly onset IBD, diagnosed after the age of 60.
Introduction: A new clinician-administered inflammatory bowel disease (IBD) Disability Index (IBDDI) was recently developed and validated among a population in France. We aimed to validate the IBDDI in a North American setting and adapt for use as a self-report tool.
Methods: Persons 18-65 years old from the population-based University of Manitoba IBD Research Registry were mailed a self-administered survey.
Background: The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC).
Aim: To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool.
Method: Systematic review of cross-sectional studies.
Background And Aims: Data on extra-intestinal manifestations [EIM] and their impact on the disease course of ulcerative colitis [UC] in population-based cohorts are scarce, particularly in paediatric- and elderly-onset UC patients. The aims of this population-based study were to assess: 1] the occurrence of EIM in paediatric- and elderly-onset UC; 2] the factors associated with EIM; and 3] their impact on long-term disease outcome.
Methods: Paediatric-onset [< 17 years at diagnosis] and elderly-onset UC patients [> 60 years at diagnosis] from a French prospective population-based registry [EPIMAD] were included.
Background And Aims: Persistent perineal sinus (PPS) defined as a perineal wound remaining unhealed more than 6 months after abdominoperineal resection (APR) is a well-known complication. The aim of our study was (1) to evaluate the incidence of PPS after APR for Crohn's disease (CD) in the era of biotherapy, (2) to determine long-term outcome of PPS, (3) to study risk factors associated with delayed perineal healing, and (4) to compare the results in this CD patient group with patients without CD.
Methods: From 1997 to 2013, the records of patients who underwent APR for CD and for non-CD rectal cancer with or without radiochemotherapy at two French university hospitals were studied retrospectively.
Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period.
Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011.
Background And Aims: Very-early-onset inflammatory bowel disease [VEO-IBD] is a form of IBD that is distinct from that of children with an older onset. We compared changes over time in the incidence and phenotype at diagnosis between two groups according to age at IBD diagnosis: VEO-IBD diagnosed before the age of 6 years, and early-onset IBD [EO-IBD] diagnosed between 6 and 16 years of age.
Methods: Data were obtained from a cohort enrolled in a prospective French population-based registry from 1988 to 2011.
Background And Aims: Infliximab and adalimumab are increasingly used to prevent postoperative recurrence in Crohn's disease patients. The impact of previous exposure to one or more anti-tumour necrosis factor [TNF] agents before surgery on the efficacy of anti-TNF therapy on postoperative recurrence is unknown.
Methods: We performed a retrospective analysis of Crohn's disease patients who underwent surgical bowel resection with anastomosis and prophylactic treatment with anti-TNF therapy between January 2005 and June 2013.