Publications by authors named "Sarra M Rahem"
Article Synopsis
- Obesity is a significant issue affecting both children and adults, but the connection between their weight changes, especially between parents and children, is not well understood.* -
- The study examined over 3,800 parent-child pairs in New York City to see if changes in BMI categories in parents influence similar changes in their children's modified BMI z-scores (mBMIz).* -
- Results showed that children often experience similar undesirable weight changes as their parents, with those having obese parents displaying more significant increases in mBMIz, highlighting the need for public health strategies targeting both parents and their children.*
Background: Prioritization of breast cancer patients based on the risk of resistance to tamoxifen plays a significant role in personalized therapeutic planning and improving disease course and outcomes.
Methods: In this work, we demonstrate that a genome-wide pathway-centric computational framework elucidates molecular pathways as markers of tamoxifen resistance in ER+ breast cancer patients. In particular, we associated activity levels of molecular pathways with a wide spectrum of response to tamoxifen, which defined markers of tamoxifen resistance in patients with ER+ breast cancer.