Publications by authors named "Sarra Bekri"
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
Bioorg Med Chem Lett
November 2020
Article Synopsis
- Researchers developed new cadiolide analogues through a one-pot multi-component synthesis to enhance antibacterial properties.
- These new compounds were tested against standard and antibiotic-resistant bacterial strains and showed promising efficacy, with minimum inhibitory concentrations (MICs) of 2 μg/mL.
- Notably, some of the most effective compounds include an indole group or a modified lactone, and they demonstrated low toxicity towards keratinocyte cells, suggesting potential for safe application in human health.