Rectus Muscle Flap-augmented Closures in Wide-gap Exstrophy Bladder.

Background: Wound dehiscence is one of the main complications in complete primary repair of exstrophy (CPRE). In our pediatric urology unit, we have switched to the use of inferior epigastric artery based rectus abdominis flap cover for abdominal wall closure in addition to measures like osteotomy and postoperative hip spica.

Aim: to assess the efficacy of Recus abdominis flap in prevenion of wound dehisence.

Concurrent Placement of the Testicular Prosthesis in Children Following Orchiectomy/Testicular Loss.

Introduction: Testis is essential for male sexual hormone production, fertility, and psychological well-being of a male. In the unfortunate event of testicular loss, placement of a testicular prosthesis perhaps will offer a sense of well-being, improved body image, and overall confidence in the growing child.

Aims: The aim is to evaluate the feasibility and assessment of outcomes following concurrent placement of testicular prosthesis in children following orchiectomy.

Role of Partial Splenectomy in Gaucher's Disease in Resource Challenged Nations.

Context: Gaucher's disease (GD) is a rare inherited metabolic disorder caused by the defective activity of glucocerebrosidase. Enzyme replacement therapy (ERT) and substrate reduction therapy are the treatment of choice. Total splenectomy has a role when the child develops complications of massive splenomegaly.

Treating rural paediatric obesity through telemedicine vs. telephone: Outcomes from a cluster randomized controlled trial.

Objective: The objective of the current study was to examine the feasibility of telemedicine vs. telephone for the delivery of a multidisciplinary weekly family-based behavioural group intervention to treat paediatric obesity delivered to families living in rural areas using a randomized controlled trial methodology.

Methods: 103 rural children and their families were recruited.

Coffee enhances the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinomas.

Unlabelled: In this study, we examined the effect of roasted coffee extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced buccal pouch carcinogenesis in male Syrian hamsters using lipid peroxidation, reduced glutathione (GSH) and glutathione peroxidase (GPx) activity as biomarkers of chemoprevention. Forty male hamsters were divided into four groups of 10 animals. The right buccal pouches of the animals in Group 1 was painted with a 0.

Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis.

We examined the extent of lipid peroxidation and the amount of reduced glutathione (GSH), and activities of the GSH-dependent enzymes, glutathione peroxidase (GPx) and glutathione S-transferase (GST), in human oral tumour tissue and 7, 12-dimethylbenz[a]anthracene-(DMBA)-induced hamster buccal pouch tumour tissues. Diminished lipid peroxidation in the oral and hamster tumours was accompanied by a significant reduction in the concentration of phospholipids and an increase in the cholesterol:phospholipid ratio. The concentration of glutathione and the activities of GPx and GST were raised in both human oral and hamster tumour tissues.

Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma.

We examined the extent of lipid peroxidation and the status of reduced glutathione (GSH) and the GSH-dependent enzymes-glutathione peroxidase (GPx) and glutathione-S-transferase (GST)-in oral tumour tissues from 33 adult oral cancer patients and an equal number of age- and sex-matched normal subjects. Diminished lipid peroxidation in the oral tumour tissue was accompanied by a significant decrease in phospholipids and an increase in the cholesterol/phospholipid (C/P) ratio. The concentration of glutathione and the activities of GPx and GST were elevated in oral tumour tissues.

The active site composition of porcine pancreatic lipase: possible involvement of lysine.

A mechanism is proposed wherein an essential lysine in porcine pancreatic lipase is the acylable residue in the catalytic mechanism of the enzyme. This mechanism involves an initial interfacial activation step were acylation first takes place in a rate-limiting step on a serine residue assisted by histidine and a carboxyl-containing residue, aspartic acid or glutamic acid, and then in a fast subsequent step the acyl group is transferred to the essential lysine residue at the catalytic site. Indirect support for the mechanism is presented.