Boltz-1: Democratizing Biomolecular Interaction Modeling.

Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce B oltz -1, an open-source deep learning model incorporating innovations in model architecture, speed optimization, and data processing achieving A lpha F old 3-level accuracy in predicting the 3D structures of biomolecular complexes. B oltz -1 demonstrates a performance on-par with state-of-the-art commercial models on a range of diverse benchmarks, setting a new benchmark for commercially accessible tools in structural biology.