Predicting the Effect of miRNA on Gene Regulation to Foster Translational Multi-Omics Research-A Review on the Role of Super-Enhancers.

Gene regulation is crucial for cellular function and homeostasis. It involves diverse mechanisms controlling the production of specific gene products and contributing to tissue-specific variations in gene expression. The dysregulation of genes leads to disease, emphasizing the need to understand these mechanisms.

A Schottky/Z-Scheme Hybrid for Augmented Photocatalytic H and HO Production.

The prodigious employment of fossil fuels to conquer the global energy demand is becoming a dreadful threat to the human society. This predicament is appealing for a potent photocatalyst that can generate alternate energy sources via solar to chemical energy conversion. With this interest, we have fabricated a ternary heterostructure of TiC nanosheet modified g-CN/BiO (MCNRBO) Z-scheme photocatalyst through self-assembly process.

Augmented photocatalysis induced by 1T-MoS bridged 2D/2D MgInS@1T/2H-MoS Z-scheme heterojunction: mechanistic insights into HO and H evolution.

In the realm of composite photocatalysts, the fusion of the co-catalyst effect with interfacial engineering is recognized as a potent strategy for facilitating the segregation and migration of photo-induced charge carriers. Herein, an innovative mediator-based Z-scheme hybrid, MIS@1T/2H-MoS, has been well designed by pairing MIS with 1T/2H-MoS a facile hydrothermal strategy as a competent photocatalyst for HO and H generation. The co-catalyst, metallic 1T-phase bridging between semiconducting 2H-MoS and MIS, serves as a solid state electron mediator in the heterostructure.

ioSearch: An approach for identifying interacting multiomics biomarkers using a novel algorithm with application on breast cancer data sets.

Identification of biomarkers by integrating multiple omics together is important because complex diseases occur due to an intricate interplay of various genetic materials. Traditional single-omics association tests neither explore this crucial interomics dependence nor identify moderately weak signals due to the multiple-testing burden. Conversely, multiomics data integration imparts complementary information but suffers from an increased multiple-testing burden, data diversity inherent with different omics features, high-dimensionality, and so forth.

Spatial Interactions in Hydrogenated Perovskite Nickelate Synaptic Networks.

A key aspect of how the brain learns and enables decision-making processes is through synaptic interactions. Electrical transmission and communication in a network of synapses are modulated by extracellular fields generated by ionic chemical gradients. Emulating such spatial interactions in synthetic networks can be of potential use for neuromorphic learning and the hardware implementation of artificial intelligence.

Low-energy quasi-circular electron correlations with charge order wavelength in BiSrCaCuO.

Most resonant inelastic x-ray scattering (RIXS) studies of dynamic charge order correlations in the cuprates have focused on the high-symmetry directions of the copper oxide plane. However, scattering along other in-plane directions should not be ignored as it may help understand, for example, the origin of charge order correlations or the isotropic scattering resulting in strange metal behavior. Our RIXS experiments reveal dynamic charge correlations over the scattering plane in underdoped BiSrCaCuO.

Nanoarchitecture of a TiC@TiO Hybrid for Photocatalytic Antibiotic Degradation and Hydrogen Evolution: Stability, Kinetics, and Mechanistic Insights.

Designing of a visible-light-driven semiconductor-based heterojunction with suitable band alignment and well-defined interfacial contact is considered to be an effective strategy for the transformation of solar-to-chemical energy and environmental remediation. In this context, MXenes have received tremendous attention in the research community due to their merits of abundant derivatives, elemental composition, excellent metallic conductivity, and surface termination groups. Meanwhile, a facile synthetic strategy for MXene-derived TiO nanocomposites with stable framework and higher photocatalytic activity under visible-light irradiation still remains a challenge for researchers.

Architecture and Kinetic Studies of Photocatalytic HO Generation and H Evolution through Regulation of Spatial Charge Transfer via Z-Scheme Path over a (001) Facet Engineered TiO@MXene/B--CN Ternary Hybrid.

Spatial charge separation and migration are the critical shortcomings dominating the core energy conversion corridors of photocatalytic systems. Here, a biomimetic multi-interfacial architecture providing strong coupled interaction and rapid charge transmission for photostable and competent photocatalytic HO production and H evolution is proposed. The triple-hybrid all-solid-state Z-scheme system was formed with the (001) facet exposed TiO nanosheets derived from MXene layers and B--CN nanosheets (M/(001)TiO@BCN) through an electrostatic self-assembly strategy with intimate electronic interaction due to Ti orbital modulation and proper stacking among the hybrids.

TiMEG: an integrative statistical method for partially missing multi-omics data.

Multi-omics data integration is widely used to understand the genetic architecture of disease. In multi-omics association analysis, data collected on multiple omics for the same set of individuals are immensely important for biomarker identification. But when the sample size of such data is limited, the presence of partially missing individual-level observations poses a major challenge in data integration.

Querying multiple sets of P-values through composed hypothesis testing.

Motivation: Combining the results of different experiments to exhibit complex patterns or to improve statistical power is a typical aim of data integration. The starting point of the statistical analysis often comes as a set of P-values resulting from previous analyses, that need to be combined flexibly to explore complex hypotheses, while guaranteeing a low proportion of false discoveries.

Results: We introduce the generic concept of composed hypothesis, which corresponds to an arbitrary complex combination of simple hypotheses.

Emergence of quenched disorder as a dominant control for complex phase diagram of rare-earth nickelates.

Competing interactions in complex materials tend to induce multiple quantum phases of comparable energetics close to the ground state stability. This requires novel strategies and tools to segregate such phases with desired control to manipulate the properties relevant for contemporary technologies. Here, we show 'quenched disorder (QD)' as a predominant control parameter to realize a broad range of the quantum phases of bulkNiO(= rare-earth ion) phase diagram in a LaEuNiOcompounds by systematic introduction of QD.

Digital- to Analog-Type Terahertz Modulation Controlled by Mosaicity of the Substrate Template in Rare-Earth Nickelate Thin Films.

The extreme sensitivity of the metal-insulator (M-I) transition in RNiO (R = rare-earth ion) nickelates to various extrinsic and intrinsic factors rely on mechanisms driving structure-property relations. Here, we demonstrate a unique way to control the M-I transition of epitaxial PrSmNiO thin films using a mosaic template of the LaAlO(100) substrate; two sets of epitaxial films were deposited on highly oriented crystals and mosaic (with multiple crystallites) crystals. While the former films exhibit a robust and sharp M-I transition, the films on the mosaic substrate show distinctively much more subtle and broad transition, albeit same factors suggesting compositional purity.

Tight clustering for large datasets with an application to gene expression data.

This article proposes a practical and scalable version of the tight clustering algorithm. The tight clustering algorithm provides tight and stable relevant clusters as output while leaving a set of points as noise or scattered points, that would not go into any cluster. However, the computational limitation to achieve this precise target of tight clusters prohibits it from being used for large microarray gene expression data or any other large data set, which are common nowadays.

A powerful method to integrate genotype and gene expression data for dissecting the genetic architecture of a disease.

To decipher the genetic architecture of human disease, various types of omics data are generated. Two common omics data are genotypes and gene expression. Often genotype data for a large number of individuals and gene expression data for a few individuals are generated due to biological and technical reasons, leading to unequal sample sizes for different omics data.

Family-based genome-wide association of inflammation biomarkers and fenofibrate treatment response in the GOLDN study.

In this paper we analyzed whole-genome genetic information provided by GAW20 from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study for family data. Lipid levels such as triglycerides (TGs) and high-density lipoprotein (HDL) are measured at different time points before and after administration of an anti-inflammatory drug fenofibrate. Apart from that, the data contain some covariates and whole-genome genotype information.

Cation disorder and epitaxial strain modulated Drude-Smith type terahertz conductivity and Hall-carrier switching in Ca Ce RuO thin films.

The CaRuO is a non-Fermi liquid pseudo-cubic perovskite with a magnetic ground state on the verge of phase transition and it lies in the vicinity of the quantum critical point. To understand the sensitivity of its ground state, the effects of subtle aliovalent chemical disorder on the static and high frequency dynamic conductivity in the coherently strained structures were explored. The Ce-doped Ca Ce RuO (0  ⩽  x  ⩽  0.