Publications by authors named "Sarmad Nory Gany"
This study aimed to investigate the potential neuroprotective effects of coenzyme Q10 in cerebral ischemia-reperfusion injury-induced neuronal damage and explore the underlying mechanisms. Twenty-eight adult male rats, weighing approximately 200-300 grams, were randomly divided into four groups: the sham group (neck dissection without ischemia), the control group (30 minutes of bilateral common carotid artery ligation followed by one hour of reperfusion), the vehicle group (oral carboxymethylcellulose solution for seven days prior to bilateral common carotid artery ligation and reperfusion), and the treatment group (seven days of coenzyme Q10 pretreatment followed by bilateral common carotid artery occlusion and reperfusion). Histopathological analysis and measurement of brain infarct size were performed, and cerebral levels of IL-6, IL-10, TNF-α, ICAM-1, NF-κB p65, and total antioxidant capacity were assessed.
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- The study investigated the protective effects of Compound 21 on kidney injury caused by lack of blood flow and subsequent restoration (ischemia-reperfusion) in male mice.
- Significant increases in indicators of kidney damage, like urea and creatinine, were observed in the ischemia-reperfusion group compared to the sham group, but these levels were notably lower in the Compound 21 group.
- The research concluded that Compound 21 effectively reduces kidney damage and inflammation by regulating the PI3K/AKT signaling pathway, leading to improved renal function after ischemia-reperfusion injury.