Beyond appendicitis: ultrasound findings of acute bowel pathology.

Bowel pathology is a common unexpected finding on routine abdominal and pelvic ultrasound. However, radiologists are often unfamiliar with the ultrasound appearance of the gastrointestinal tract due to the underutilization of ultrasound for bowel evaluation in the USA. The purpose of this article is to familiarize radiologists with the characteristic ultrasound features of a variety of bowel pathologies.

Esophageal transit scintigraphy in children: a user's guide and pictorial review.

Technical and clinical aspects of esophageal transit scintigraphy in pediatric patients are reviewed via several illustrative cases that highlight its utility in evaluating primary and secondary esophageal motility disorders.

Tunable phonon blockade in weakly nonlinear coupled mechanical resonators via Coulomb interaction.

Realizing quantum mechanical behavior in micro- and nanomechanical resonators has attracted continuous research effort. One of the ways for observing quantum nature of mechanical objects is via the mechanism of phonon blockade. Here, we show that phonon blockade could be achieved in a system of two weakly nonlinear mechanical resonators coupled by a Coulomb interaction.

Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy.

Background: Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key hallmark in cardiomyopathy, studies have been inconsistent in the types of alterations involved. In this study human cardiomyocytes were exposed to an environmental nutritional perturbation of high glucose, fatty acids, and l-carnitine to model DCM and iTRAQ-coupled LC-MS/MS proteomic analysis was used to capture proteins affected by the perturbation.

A Comparative Evaluation of Time-dependent Changes on the Surface Hardness of Bulk Cure Composites: An Study.

Objectives: The objective of this study was to assess the surface hardness through Vickers hardness (VH) test of one conventional hybrid resin composites (Filtek Z350), compared with that of two bulk cure resin composites (SDR™, Tetric N Ceram®).

Materials And Methods: Twenty specimens of each material were prepared in cylindrical aluminum molds with an internal diameter of 5 mm and depth of 4 mm, 10 (incremental curing) and 10 (bulk curing).The surface of each specimen was covered with a transparent plastic matrix strip before light curing with conventional visible light for 40 seconds.

Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort.

Objective: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission.

Research Design And Methods: This ancillary longitudinal study among participants in the Diabetes Control and Complications Trial (DCCT) and observational follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) (652 women and 713 men) was conducted in 2003 and 2010/2011.

Molecular characterisation of virulent gene in clinical isolates from patients with gastroduodenal diseases in Assam, India.

Background: Helicobacter pylori, the gastric bacterium, is widely known to be one of the most genetically diverse group of organisms whose pathogenesis as well as the diversity in infection outcome may be attributed to a variety of virulent genes.

Aim: This study aimed to study the molecular profile of H. pylori vacA gene by determining the phylogenetic relatedness and genetic diversity of the strains isolated in this region with those of other geographical regions.

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients.

Cathepsin S (CTSS) activity is elevated in Sjögren's Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears, which could lead to enhanced CTSS-driven degradation of tear proteins. CTSS activity against Cys C, LF and sIgA was tested in SS or healthy control tears.

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF.

Objectives: This study evaluated the associations of obesity and cardiometabolic traits with incident heart failure with preserved versus reduced ejection fraction (HFpEF vs. HFrEF). Given known sex differences in HF subtype, we examined men and women separately.

Pregnancy Among Survivors of Childhood Cancer: Cardiovascular Considerations.

Purpose Of Review: To educate clinicians on cardiovascular considerations and management strategies surrounding pregnancy in childhood cancer survivors.

Recent Findings: With advances in oncologic treatment, growing numbers of childhood cancer survivors are now able to consider pregnancy. A significant proportion of survivors have received cardiotoxic therapy, particularly anthracyclines, and/or chest radiation.

Hypokalemic Paralysis Due to Primary Sjogren Syndrome.

Sjögren syndrome is an autoimmune disorder characterized by lymphocytic infiltration of exocrine gland. The most common symptom by virtue of its involvement includes dryness of eyes, mouth, and parotid gland enlargement. However, the disease may be associated with extraglandular manifestation affecting multiple organs.

Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance.

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

This corrects the article DOI: 10.1038/nm.4484.

Management of a Rare Variant of Hypertrophic Cardiomyopathy.

Apical hypertrophic cardiomyopathy (HCM) is a rare variant of HCM. We present the case of a 26-years-old female who was diagnosed with apical HCM. Her electrocardiogram showed the characteristic T-wave inversions in V2-V5 and her echocardiogram portrayed apical left ventricular hypertrophy.

Ipsilateral Ptosis and Contralateral Ataxic Hemiparesis as Initial Symptoms of Combined Tuberothalamic and Paramedian Artery Infarction.

Thalamic infarcts, accounting for approximately 14% of lacunar infarcts, exhibit varied clinical manifestations due to complex anatomy of nuclei and varying blood supply. Pure and combined types of thalamic infarctions have been summarized in some paper, but information of cerebral angiography was not mentioned. Here we report a rare case of combined tuberothalamic and paramedian artery occlusion presenting with ipsilateral ptosis and contralateral ataxic hemiparesis.

Fast and efficient wireless power transfer via transitionless quantum driving.

Shortcut to adiabaticity (STA) techniques have the potential to drive a system beyond the adiabatic limits. Here, we present a robust and efficient method for wireless power transfer (WPT) between two coils based on the so-called transitionless quantum driving (TQD) algorithm. We show that it is possible to transfer power between the coils significantly fast compared to its adiabatic counterpart.

Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents.

A new series of Schizandrin (1) derivatives were synthesized utilizing the C-9 position of the Schizandrin core and evaluated for their cytotoxic activities against HeLa (cervical cancer), A549 (lung cancer), MCF-7 (breast cancer) and DU-145 (prostate cancer) cell lines. Among the synthesized series, 4e, 4f, 4g and 5 showed potent activities against tested cell lines. More significantly, compound 5 exhibited most potent cytotoxic activity against DU-145 with an IC value of 1.

Highly amplified light transmission in a parity-time symmetric multilayered structure.

We propose a parity-time symmetric dielectric-nano-film-dielectric multilayered structure that could facilitate highly amplified transmission of optical power in the infrared spectrum. We have theoretically studied our model using the transfer-matrix formalism. The reflection and the transmission coefficients of the S-matrix are evaluated.

Deep Neck Space Infections-A Study in Diabetic Population in a Tertiary Care Centre.

This study is intended to analyze the clinical profile and outcomes of deep neck space infection in diabetic patients in our tertiary care centre. A prospective study of 1 year duration from 30th September 2015 to 30th September 2016 at department of Otorhinolaryngology, Gauhati Medical College and Hospital, Guwahati. A total of 45 diabetic patients who presented with DNSI are included in this study.

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD leukemia cells. This synergized with the allogeneic CD8 T cell response, leading to long-term survival in six mouse models of FLT3-ITD AML.

Molecular identification and detection of virulent factors in from gastric biopsy samples of patients attended at Assam Medical College and Hospital, Dibrugarh, Assam, India.

The present study aimed to detect the major virulence determinants of Helicobacter pylori, the gastric bacteria by polymerase chain reaction from genomic DNA of 314 gastric biopsies from dyspeptic patients in 2015-2016 through upper gastrointestinal endoscopy. In 153 cases out of 314, the high prevalence of oipA gene followed by cagA-vacA s1 m1 combined genotypes was found in mostly gastritis/duodenitis patients followed by the peptic ulcer and normal patients. Therefore, the clinical significance of the virulence markers of H.

Rapid calibration of an intracortical brain-computer interface for people with tetraplegia.

Objective: Brain-computer interfaces (BCIs) can enable individuals with tetraplegia to communicate and control external devices. Though much progress has been made in improving the speed and robustness of neural control provided by intracortical BCIs, little research has been devoted to minimizing the amount of time spent on decoder calibration.

Approach: We investigated the amount of time users needed to calibrate decoders and achieve performance saturation using two markedly different decoding algorithms: the steady-state Kalman filter, and a novel technique using Gaussian process regression (GP-DKF).