Publications by authors named "Sarkis Saruhanian"
Primary open-angle glaucoma (POAG) is subdivided depending on eye pressure. Patients with normal-tension glaucoma (NTG) have never had high intraocular pressure (IOP) measured while patients with ocular hypertension (OHT) have high eye pressure but no signs of glaucoma. Although IOP is considered to be a risk factor for all glaucoma patients, it is reasonable to assume that other risk factors such as inflammation play a role.
View Article and Find Full Text PDFGlaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role.
View Article and Find Full Text PDFIncreasing evidence indicates that changes in the redox system may contribute to the pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the neurodegeneration of the inner-most retinal neurons, the retinal ganglion cells (RGCs), and their axons, which form the optic nerve. Often, optic neuropathies are asymptomatic until advanced stages, when visual impairment or blindness is unavoidable despite existing treatments.
View Article and Find Full Text PDFBackground: Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients. They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells (RGCs) and Müller glia.
Aim: To refine human-induced pluripotent stem cells (hiPSCs) differentiated into three-dimensional (3D) retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.
Article Synopsis
- Increased intraocular pressure (IOP) is the primary risk factor for primary open-angle glaucoma (POAG), but many patients show a normal IOP, leading to the category of normal-tension glaucoma (NTG).
- A study indicates that other factors beyond IOP contribute to glaucoma, particularly focusing on the retina's oxygen supply and regulation.
- Patients with ocular hypertension (OHT) demonstrate a higher capacity for managing fluctuating oxygen levels and possess more antioxidants, suggesting they are less prone to neurodegeneration associated with glaucoma.