Phytometabolites, Pharmacological Effects, Ethnomedicinal Properties, and Bioeconomic Potential of Velvet Apple (Diospyros discolor Willd.): A Review.

Diospyros discolor Willd., commonly known as Velvet apple or Mabolo, is an underutilized fruit. Traditionally, various parts of D.

The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and Oxidative Stress Biomarkers in High-Fat-Sugar Diet-Fed Rats.

The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD). The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed-phase high-performance liquid chromatography (RP-HPLC). Two specific doses of MPT, namely, 250 and 500 mg/kg body weight (BW), were chosen for the study-referred to as MPT-250 and MPT-500, respectively.

Intraperitoneal Steroid Therapy for Recurrent Malignant Ascites in Advanced Cancer Patients: A Case Series.

Intraperitoneal administration of depot corticosteroids following an initial paracentesis reduces ascitic fluid formation and extends the interval between subsequent paracentesis sessions. This approach may effectively manage recurrent malignant ascites and enhance patients' quality of life.

Evidence of an emerging triple-reassortant H3N3 avian influenza virus in China.

The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated A/chicken/China/16/2023 (H3N3), was isolated from a sick chicken in northern China. The complete genome of the isolate was determined using next-generation sequencing, and the AIV-like particles were confirmed via transmission electron microscopy.

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation.

Molecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades. The Ras homolog gene family member A (RhoA) is one of the molecular switches that binds with GTP in order to cycle between an active GTP-bound state and an inactive GDP-bound state. Any aberrance in control over this circuit, particularly due to any perturbation in switching, leads to the development of different pathogenicity.

Effectiveness of prenatal intervention on neonatal hyperbilirubinemia management in rural Bangladesh: Results from a cluster-randomized trial.

Objectives: Nearly 80 % of severe neonatal hyperbilirubinemia cases are identified too late for medical treatment in lower-middle-income countries. Parents' understanding of neonatal jaundice is crucial for early detection and effective treatment. This study evaluated the effectiveness of prenatal sensitization in improving maternal knowledge and attitude toward neonatal hyperbilirubinemia management in Bangladesh.

Development of a Tandem Mass Spectral Library for the Detection of Triterpenoids in Plant Metabolome Based on Reference Standards.

Plant triterpenoids represent a diverse group of secondary metabolites and are thought to be valuable for therapeutic applications. For drug development, lead optimization, better knowledge of biological pathways, and high-throughput detection of secondary metabolites in plant extracts are crucial. This paper describes a qualitative method for the rapid and accurate identification of various triterpenoids in plant extracts using the LC-HR-ESI-MS/MS tool in combination with the data-dependent acquisition (DD) approach.

Next generation legged robot locomotion: A review on control techniques.

The next generation of autonomous-legged robots will herald a new era in the fields of manufacturing, healthcare, terrain exploration, and surveillance. We can expect significant progress in a number of industries, including inspection, search and rescue, elderly care, workplace safety, and nuclear decommissioning. Advanced legged robots are built with a state-of-the-art architecture that makes use of stereo vision and inertial measurement data to navigate unfamiliar and challenging terrains.

Prevalence of overweight and obesity and their impact on academic performance and psychological well-being among university students in 2024 in Bangladesh.

Background: The prevalence and impact of obesity and overweight is one of the main concerns among researchers worldwide. There are several consequences of overweight and obesity among students in developing countries like Bangladesh. Therefore, this study aims to explore the prevalence and impact of overweight or obesity on individuals' self-esteem and academic performance among university students in Bangladesh.

Bond behavior of confined rebar in recycled brick aggregate concrete using bending pullout test.

The pertinence of recycled brick aggregate (RBA) in concrete structures largely depends on their bonding ability with the rebars. Considering the practical detailing of concrete structures where main rebars are usually confined by stirrups, this study conducted bending pullout tests on 12 beam specimens to study the influence of concrete confinement on the bond behavior of rebar in RBA concrete. The investigated variables include RBA%, rebar diameter (), embedment length ( ), and the ratio of concrete cover to rebar diameter ().

Exploring newly isolated thermotolerant, halotolerant and antimicrobial resistant Bacillus subtilis ProNTL1 from tannery waste and its alkaline protease production.

Background: A hydrolytic enzyme called protease from microbial sources has expansive applications in leather as well as tannery industries and thus leaves no choice but to discover a potential candidate for efficient yield of protease with eccentric characteristics.

Methods And Results: In the current study, using skim milk agar medium, three bacterial strains (Pro SS14, Pro NTL1, Pro SM) were identified for protease production out of thirty tannery waste samples. The bacterial isolates were identified through morphological, biochemical and molecular basis and the highest protease producer (134 U/mL) having the paramount protein content (8.

Osteoporosis incidence and its associated factors in the older Korean population: findings from a population-based cohort study.

Unlabelled: In South Korea, osteoporosis incidence among the elderly was unclear. Our study revealed an incidence of 18.4 per 1000 person-years, with higher rates in females and those with lower education.

Next generation power inverter for grid resilience: Technology review.

Distributed generation (DG) systems are becoming more popular due to several benefits such as clean energy, decentralization, and cost effectiveness. Because the majority of renewable energy sources provide DC power, power electronic inverters are necessary for their conversion from DC to AC power. To fulfill this demand, the next generation power inverter employs innovative technologies while simultaneously assuring stability and resilience.

Fabrication of sustainable functional cotton fabric with silk sericin and chitosan for protective textiles.

The use of bio-based sources for producing multifunctional cotton fabric with UV-protective and antibacterial properties is essential. Hence, the primary aim of this work was to develop sustainable functional cotton fabric (antibacterial and UV-protective) by applying silk sericin and chitosan using a simple and environmentally benign pad-dry curing method. The modification as well as functional properties of the treated fabric were evaluated in terms of antimicrobial efficacy, moisture management, UV protection, scavenging activity, surface morphology, thermal stability and mechanical strength.

Evaluating the effectiveness of the 'eco-cooler' for passive home cooling.

Constructed with used plastic bottles, the eco-cooler has been widely adopted in resource-poor communities in Bangladesh and other countries. We tested the eco-cooler under controlled conditions using a scientific wind tunnel in a climatic chamber. In our tests, we used seven eco-cooler designs in 27 climate conditions typical of Bangladesh (temperatures of 40 °C, 35 °C, and 30 °C; humidity levels of 70%, 60%, and 40%; and wind speeds of 4.

Azobenzene-Tagged Photopeptides Exhibiting Excellent Selectivity and Light-Induced Cytotoxicity in MCF-7 Cells over HeLa and A549.

The precise regulation of proteasome activity has become a focal point in current research, particularly its implications in cancer treatment. Bortezomib is used for treating multiple myeloma and is found to be ineffective against solid tumors. A spatiotemporal control over the proteasome is one of the solutions to resolve these issues using external stimuli, such as light.

Oleanolic acid purified from the stem bark of Oliv. inhibits the function and catalysis of human 17-hydroxysteroid dehydrogenase 1.

Cancer is a leading cause of global death. Medicinal plants have gained increasing attention in cancer drug discovery. In this study, the stem bark extract of , which is used in ethnomedicine to treat cancer, was subjected to phytochemical investigation leading to the isolation of oleanolic acid (OA).

A generic cell-based biosensor converts bacterial infection signals into chemoattractants for immune cells.

Bacterial infection is a major challenge to human health. Although various potent antibiotics have emerged in recent decades, current challenges arise from the increasing number of multi-drug-resistant species. Infections associated with implants represent a particular challenge because they are usually diagnosed at an advanced stage and are difficult to treat with antibiotics owing to the formation of protective biofilms.

In Vitro Cytotoxicity and Antimicrobial Activity against Acne-Causing Bacteria and Phytochemical Analysis of Galangal () and Bitter Ginger () Extracts.

Galangal ( (L.) Willd) and bitter ginger ( (L.) Roscoe) are aromatic rhizomatous plants that are typically used for culinary purposes.

Correction: Understanding patient and family experiences of critical care in Bangladesh and India: What are the priority actions to promote person-centred care?

[This corrects the article DOI: 10.1371/journal.pgph.

Metagenomic Detection of Multiple Viruses in Monk Parakeet (Myiopsitta monachus) in Australia.

Background: Birds are known to harbour many pathogens, including circovirus, herpesviruses, adenoviruses and Chlamydia psittaci. Some of these pose zoonotic risks, while others, such as beak and feather disease virus (BFDV), have a significant impact on the conservation of endangered bird species.

Objectives: This study was aimed to determine the faecal virome of a group of apparently healthy Monk parakeet using high-throughput sequencing.

Effectiveness of a Single Intra-articular Injection of High-Molecular-Weight Hyaluronic Acid Versus NSAIDs on the Visual Analog Pain Scale and Western Ontario and McMaster Universities Osteoarthritis Index Scores in Patients With Knee Osteoarthritis.

Objective: This study aimed to determine the effectiveness of a single intra-articular injection of high-molecular-weight (HMW) hyaluronic acid (HA) at a dose of 4 mL/60 mg to reduce pain in people with knee osteoarthritis (OA) over 12 months.

Methodology: This retrospective study was conducted after obtaining ethical approval from Dhaka Medical College and Hospital, Bangladesh. From July 2020 to June 2021, a medical professional conducted the investigation.