Decoding the genomic landscape of sp. RAM2 isolated from flacherie-infected L.

Species of the genus are recognized as opportunistic zoonotic pathogens. Here, we report the draft genome sequence of sp. RAM2, isolated from a flacherie-infected L.

Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report.

Background: Cardiac light-chain amyloidosis represents a critical component of this multi-systemic disease, significantly impacting prognosis. The extent of cardiac free light-chain deposition is the primary determinant of survival.

Case Presentation: We report the case of a 67-year-old male with a 10-year history of diabetes mellitus and arterial hypertension who presented with a two-day history of chest discomfort and difficulty lying down or sleeping, along with a two-month history of progressively worsening exertional dyspnea.

The effect of position of anterior humeral line on elbow function after pediatric supracondylar fracture of humerus: A prospective observational study.

Objective: To determine the influence of various Anterior humeral line (AHL) positions on elbow function after complete healing of pediatric supracondylar humerus fractures.

Methods: A prospective study was carried out in 4-year to 14-year-old children presenting with supracondylar fracture at elbow. The intra and post-operative radiographs were assessed for the position of AHL to capitellum on a lateral radiograph.

Electronic structure of mononuclear and radical-bridged dinuclear cobalt(II) single-molecule magnets.

Metal-organic compounds that feature magnetic bistability have been proposed as bits for magnetic storage, but progress has been slow. Four-coordinate cobalt(II) complexes feature high inversion barriers of the magnetic moment, but they lack magnetic bistability. Developing radical-bridged polynuclear systems is a promising strategy to encounter this; however detailed investigations of such species are scarce.

Targeting cyclin-dependent kinase 2 (CDK2) interactions with cyclins and Speedy 1 (Spy1) for cancer and male contraception.

The review discusses progress in discovering cyclin-dependent kinase 2 (CDK2) inhibitors for cancer treatment and their potential for male contraception. It summarizes first-, second-, and third-generation CDK inhibitors and selective CDK2 inhibitors currently in clinical trials for cancer. Novel strategies to discover allosteric inhibitors, covalent inhibitors, and degraders are also discussed.

Identification of novel thiazole derivatives as flaviviral protease inhibitors effective against Dengue (DENV2) and Japanese encephalitis viruses.

Flaviviruses are the causative agents of viral hemorrhagic fever (VHF) globally and have demonstrated the capacity to result in fatal outcomes if not managed effectively. Among different types of flaviviruses, dengue (DENV) and Japanese encephalitis (JEV) viruses are the most common in tropical and subtropical countries. While vaccines have been developed and licensed for both DENV and JEV, effective treatment options remain sparse.

Transformation of agriculture to inland aquaculture in the coastal plains of West Bengal, India.

Traditional agriculture has a notable shift towards inland aquaculture driven by geo-environmental hazards and socio-economic choices. This shift is crucial for ensuring economic resiliency and food security. Therefore, the present study examines the transformation of agricultural land to inland aquaculture among the three community development (C.

Enhanced antimycotic activity of biomodified copper oxide nanoparticles from indigenous state flowers of Jharkhand: an and approach.

Current study investigates the medicinal applications of (Palash), the state flower of Jharkhand, India, focusing on synthesising biomodified copper oxide nanoparticles (CuO-NPs) and its antifungal properties. Flavonoid content in the flower extract was quantified by aluminium chloride colorimetric analysis. CuO-NPs were synthesised via co-precipitation method and then modified with methanolic flower extract.

End tuberculosis strategy also requires initiation and integration of a national silicosis control program with the ongoing tuberculosis elimination activities: A review of the silicotuberculosis situation in India.

Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India's significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure.

Leveraging N- substituents to tune the donor/acceptor properties of mesoionic imines (MIIs).

In this work, we show two synthetic routes to substitute the N position of mesoionic imines (MIIs). By Buchwald-Hartwig amination, 5-amino-1,2,3-triazoles can be arylated at the said position, showing the versatility of amino-triazoles as building blocks for MIIs. The reaction of MIIs with electrophiles (MeI, fluoro-arenes) highlights the nucleophilic nature of MIIs as even at room temperature aromatic C-F bonds can be activated with MIIs.

An Anionic Mesoionic Carbene (anMIC) and its Transformation to Metallo MIC-Boranes: Synthesis and Properties.

Neutral mesoionic carbenes (MICs) based on a 1,2,3-triazole core have had a strong impact on various branches of chemistry such as homogeneous catalysis, electrocatalysis, and photochemistry/photophysics. We present here the first general synthesis of anionic mesoionic carbenes (anMICs, 2) based on a 1,2,3-triazole core and a borate backbone. The free anMIC is stable in solution under an inert atmosphere at low temperatures, and can be stored for several weeks.

Dietary Chia (Salvia hispanica L.) seeds oil supplementation augments growth performance and gut microbial composition in Labeo rohita fingerlings.

The present study investigates the supplemental effects of chia seed oil (CSO) on the growth performance and modulation of intestinal microbiota in Labeo rohita fingerlings. Four diets were formulated with graded levels of CSO: 1.0%, 2.

Prevalence of Substance Use and Sleep-Related Problems Among Driver Victims Involved in Road Traffic Accidents Presenting to a Tertiary Care Hospital in India.

Background: Road traffic accidents (RTAs) are a critical public health problem leading to significant morbidity, mortality, and socioeconomic losses. Despite known risk factors like substance use and sleep-related problems, there is limited research on the prevalence of these factors among drivers who met with RTAs. Hence, this study aimed to gain insight into the prevalence of substance use and sleep-related problems among this population attending a trauma center in the northern State of India.

Assessment of fish habitat suitability in the wake of elevated pollution of a tropical river in India.

Evaluating fish habitat suitability (FHS) is of utmost importance in the present times, as rising pollution and ecological stress have led to the deterioration of their habitat and population. The present study has evaluated ecological water quality using the comprehensive pollution index (CPI), eutrophication index (EI), and organic pollution index (OPI). Fish community structure has been assessed based on tropic level score (TLC) and habitat orientation score (HOS).

Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene.

CXCR4, a chemokine receptor known as Fusin or CD184, spans the outer membrane of various human cells, including leukocytes. This receptor is essential for HIV infection as well as for many vital cellular processes and is implicated to be associated with multiple pathologies, including cancers. This study employs various computational tools to investigate the molecular effects of disease-vulnerable germ-line missense and non-coding SNPs of the CXCR4 gene.

Bilateral Traumatic Posterior Hip Dislocation - A Case Report.

Introduction: Although posterior dislocation of the hip is common, bilateral posterior hip dislocation in children is an infrequent presentation. Early diagnosis and treatment are of paramount importance to prevent complications. Here, we report a case of traumatic bilateral posterior hip dislocation following a high-velocity motor vehicle accident.

An assessment of the influence of trade-off optimization in commercial knowledge based planning library creation for tongue cancer patients.

This article aims to compare the dosimetric performance between knowledge-based plan (KBP) libraries with and without trade-off (TO) exploration using multicriterial optimization (MCO) for tongue cancer patients. The trade-off optimized library (KBP_MCO) contains a minimal number of constituent plans, whereas two nontrade-off optimized libraries contain a minimal and a large number of treatment plans, respectively. Three KBP libraries were created: KBP_100 and KBP_20, each comprising of 100 and 20 manually optimized plans, respectively.

Association Between Information and Communication Technologies (ICTs) and Women's Attitudes Toward Intimate Partner Violence: Evidence from Bangladesh Demographic and Health Survey 2017-2018.

Many women justify intimate partner violence (IPV), resulting in adverse health outcomes. This study investigates the relationship between household ownership of information and communication technologies (ICTs), along with the frequency of listening to the radio and watching television with women's attitudes towards IPV in Bangladesh. The cross-sectional study analyzed a weighted sample of 20,032 women and used a multivariable logistic regression analysis to determine the association between predictor variables and outcome variables.

An overview of extraction, isolation and characterization techniques of phytocompounds from medicinal plants.

Medicinal plants have been used since time immemorial for the treatment of many types of diseases along with epidemics. They show many biological activities like anti-inflammatory, antioxidant, anti-insecticidal, antibiotic, anti-parasitic, anti-hemolytic properties etc. Different types of bioactive compounds, present in the medicinal plants, play a key role in prevention of diseases and also used for manufacturing medicines.

Surgical management of thoracolumbar burst fractures by three different posterior techniques: A prospective comparative study.

Study Design: Prospective Comparative Study.

Objectives: This study aims to study the outcome of thoracolumbar burst fractures by comparison of 3 different posterior constructs groups of patients treated by the posterior approach.

Setting: University level Tertiary care Centre of Northern India.

UPLC-QToF-MS/MS screening and characterization of Wight and in vitro assessment of its antioxidant, anticancer, and anti-inflammatory potential.

belongs to the Lamiaceae family and is locally known as Badichang or mahasindhu. In this study, we performed Soxhlet extraction to prepare methanolic and hydromethanolic extracts, followed by quantification of their total phenolic content and total flavonoid content. Qualitative analysis of both the extracts was conducted to determine the presence of different phytochemicals.