Publications by authors named "Saritha Theegala"
Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells.
Am J Physiol Gastrointest Liver Physiol
November 2009
Article Synopsis
- Somatostatin (SST) increases butyrate absorption in human intestinal cells by enhancing the transporter's (MCT1) activity and surface expression.
- The study shows that SST's effect is dose-dependent, peaking at 50 nM, and involves the p38 MAP kinase signaling pathway.
- SST also boosts the interaction between MCT1 and CD147, which is crucial for MCT1's function, further supporting the enhanced butyrate uptake.