CDS-Compare: A Web Application for Machine Learning Assisted Curation of Clinical Order Sets.

Order sets that adhere to disease-specific guidelines have been shown to increase clinician efficiency and patient safety but curating these order sets, particularly for consistency across multiple sites, is difficult and time consuming. We created software called CDS-Compare to alleviate the burden on expert reviewers in rapidly and effectively curating large databases of order sets. We applied our clustering-based software to a database of NLP-processed order sets extracted from VA's Electronic Health Record, then had subject-matter experts review the web application version of our software for clustering validity.

Contribution of arginase to manganese metabolism of Aspergillus niger.

Aspects of manganese metabolism during normal and acidogenic growth of Aspergillus niger were explored. Arginase from this fungus was a Mn[II]-enzyme. The contribution of the arginase protein towards A.

Aging may be a conditional strategic choice and not an inevitable outcome for bacteria.

Aging is known in all organisms that have different somatic and reproductive cells or in unicellular organisms that divide asymmetrically. Bacteria that divide symmetrically were believed to be immune to natural aging. The demonstration of functionally asymmetric division and aging in Escherichia coli recently has challenged this belief and led to the suggestion that aging might be inevitable for all life forms.