Publications by authors named "Sarina Surey"
The treatment of spinal cord injury (SCI) is a complex challenge in regenerative medicine, complicated by the low intrinsic capacity of CNS neurons to regenerate their axons and the heterogeneity in size, shape and extent of human injuries. For example, some contusion injuries do not compromise the dura mater and in such cases implantation of preformed scaffolds or drug delivery systems may cause further damage. Injectable in situ thermosensitive scaffolds are therefore a less invasive alternative.
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- The study investigates how the antagonist Decorin affects scar formation and wound healing in injured spinal cords of rats, focusing on acute and chronic dorsal funicular lesions (DFL).
- Decorin treatment significantly reduced various injury parameters, including wound cavity size and fibrotic tissue markers, more effectively in acute injuries compared to chronic ones.
- The findings suggest Decorin's primary role in acute injuries is to limit scar formation and inflammation by targeting TGF-β1/2, while in chronic injuries, it enhances the tissue remodeling process through the modulation of certain proteins involved in healing.