Publications by authors named "Sare Gulfem Ozlu"

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, mostly complement-mediated thrombotic microangiopathy. The majority of patients are infants. In contrast to infantile-onset aHUS, the clinical and genetic characteristics of adolescence-onset aHUS have not been sufficiently addressed to date.

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Background: Acute kidney injury (AKI) is a common and important complication of burn injury. Although there are numerous adult studies, data regarding AKI in pediatric burn patients are scarce. Here, we aimed to evaluate the frequency, clinical features, and prognosis of AKI among pediatric burn injury patients.

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Article Synopsis
  • Two devastating earthquakes in Türkiye on February 6, 2023, resulted in significant injuries to 903 children, with a focus on crush syndrome-related acute kidney injury (Crush-AKI) and mortality.
  • The study tracked various factors, including the time under rubble, treatment protocols, and patient outcomes, revealing that Crush-AKI developed in 36% of the patients, and over half required dialysis.
  • Key findings included that serum levels of creatine phosphokinase above 20,950 U/L and inadequate initial intravenous fluid volume were linked to Crush-AKI, and most deaths occurred among those with Crush-AKI within the first four days of admission.
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Article Synopsis
  • Acute kidney injury (AKI) is a significant risk in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), with a 16.9% incidence rate and a concerning link to higher mortality and morbidity.
  • A study of 278 patients identified key risk factors for AKI, including older age, certain complications like sinusoidal obstruction syndrome and hemorrhagic cystitis, and the use of nephrotoxic drugs like calcineurin inhibitors.
  • The findings highlight the urgent need for early detection and management strategies to reduce AKI-related risks and improve patient outcomes in children after HSCT.
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Renal artery entrapment (RAE) by hypertrophic diaphragmatic crura is an extremely rare cause of renovascular hypertension (RVH). Here, we report the case of a 9-year-old boy diagnosed with RVH caused by right RAE by a hypertrophic diaphragmatic crus and successfully managed with close medical monitoring. Diagnosis of this entity is easily overlooked if the optimal views are not obtained during imaging, which depends on a high index of suspicion.

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Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey.

Materials And Methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11 March 2020 and 11 March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry.

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Background: It is already known that viral infections, exclusively upper respiratory tract infections may trigger relapses of nephrotic syndrome. Recently, COVID-19 disease has also been reported to be related with relapse of nephrotic syndrome in a few pediatric cases Case. Here we present an 8-year-old boy who had relapse of nephrotic syndrome due to COVID-19 infection.

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A 16-year-old girl was admitted to the hospital for the absence of a menstrual bleeding over 10 mounts. She has had regular menstrual periods since she was 13 years old and no history of systemic disease. Laboratory tests showed low estrogen (<11.

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Background: Proteinuria (both tubular and glomerular in origin) and its implications are well-known features of adult patients with COVID19. However currently studies addressing proteinuria and its role in the outcome of kidney and patients of pediatric COVID 19 is scarce. We aimed to evaluate the presence of microalbuminuria in order to detect early renal involvement in pediatric COVID 19 patients.

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Background: Atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone.

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Objective: Enuresis is a major problem affecting both the child and his family. This study aimed to investigate the effect of enuresis on mother acceptance-rejection perceived by children.

Material And Methods: Fourty-six children and their mothers with the diagnosis of primary enuresis were included in the study.

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Introduction: Parvovirus B19 infection generally presents as a transient viral illness in children but rarely shows systemic lupus erythematosus-like symptoms.

Case Report: Here we present a 7-year-old girl with parvovirus B19 infection who had prolonged fever, rash, pancytopenia and hypocomplementemia making it difficult do differentiate from the first episode of systemic lupus erythematosus. Because she had severe progressive pancytopenia she was administered intravenous immune globulin treatment and her clinical course was dramatically improved.

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Background: Although there are data showing that the frequency of hypertension increases in adults with migraine, there has been no study on this subject in children. In this study, we aimed to evaluate the presence of hypertension in children with migraine by performing ambulatory blood pressure monitoring (ABPM).

Methods: Thirty-seven children diagnosed with migraine and 30 healthy controls were evaluated between January 2015 and March 2016.

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Background: The aim of this study was to investigate the histopathological findings in kidney biopsies in children with atypical hemolytic uremic syndrome (aHUS) and to determine whether specific pathological findings in aHUS have a prognostic value.

Methods: Renal biopsy specimens of 29 patients who were recorded in the national Turkish aHUS registry database were available for review. Histopathological findings were compared with the clinical and laboratory features at the presentation and the final outcome.

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