Central nervous system vasculopathy: inherited or acquired? The DADA2 conundrum.

Young people with stroke require detailed investigation because uncommon causes are more likely. A 19-year-old woman presented with multiple cortical and subcortical infarcts, arterial aneurysms, anaemia and hypertension. Further evaluation identified a systemic vasculopathy secondary to a deficiency of adenosine deaminase 2, a rare treatable monogenic disorder.

C7-T1 Full-Endoscopic Posterior Foraminotomy and Sequestrectomy Using Navigation.

The main objective of this case and video is to demonstrate the surgical technique of navigated full-endoscopic decompression and sequestrectomy at the C7-T1 level to alleviate C8 nerve root compression and manage cervicobrachialgia. Cervicobrachialgia resulting from C7-T1 disc herniation is a quite rare yet painful condition that can significantly impair motor function in the upper limb. Traditionally, open surgeries can be invasive, with prolonged recovery times and/or fusion of the level with adjacent segment disease.

Advanced thyroid nodule detection using ultrasonography image analysis and bilateral mean clustering strategies.

This research work focuses on developing an advanced diagnostic method for thyroid nodules using ultrasonography images. The core idea revolves around the observation that the presence and amount of calcium flecks in thyroid nodules can indicate their severity, potentially leading to severe thyroid cancer. A novel technique, named Bilateral Mean Clustering Strategy (Bi-MCS), is proposed, combining the strengths of Fuzzy C mean and K-mean clustering approaches.

Understanding ultrasonographic renal length-to-aorta ratio in Sighthounds: A breed specific study in Chippiparai dogs.

Ultrasonographic renal length-to-aorta ratio is an ideal reflection of renal health in dogs. Earlier studies have highlighted the need for breed-specific reference intervals for this parameter. The aim of this study was to establish a breed-specific reference interval of kidney length to aorta ratio (KL:Ao) in Chippiparai dogs, a breed of Indian sighthounds.

Evaluation of a synergistic blend of short- and medium-chain fatty acids as a dietary intervention for the effective management of Vibriosis in shrimp culture.

Vibriosis caused by Vibrio spp. is imposing severe havoc and adverse effects on shrimp culture. Antibiotics are the most widely used therapeutic measures against vibriosis.

Tampa difficulty score: a scoring system for difficulty of robotic pancreaticoduodenectomy.

Robotic platforms are increasingly utilized in surgery, offering unique technical advantages, though there is a scarcity of difficulty scoring systems (DSS) for these procedures. DSS aids in understanding operative complexities and enhancing preoperative planning. With IRB approval, data were collected on 200 consecutive adult patients who underwent robotic pancreaticoduodenectomy at a high-volume institution from 2019 to 2022.

Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

Integrating Sentinel-1 data and machine learning for effective paddy field monitoring in Cauvery Delta Zone, Tamil Nadu, India.

Paddy crop mapping is essential for agricultural monitoring, ensuring food security, and enhancing resource allocation. This study observes the Cauvery Delta Zone (CDZ), recognized as the rice bowl of Tamil Nadu and a crucial area for paddy farming in India. The study seeks to elucidate rice-growing trends over three years (2021-2023) by examining the regional variability of the Radar Vegetation Index (RVI) throughout a paddy crop growing season (June to September).

Implementation of high step up converter using RBFN MPPT controller for fuel cell based electric vehicle application.

Fuel cell-based electric vehicles (EVs) are gaining popularity in the automotive industry due to strict carbon emissions and fuel efficiency regulations. Fuel cells have inherently low voltage characteristics, making it challenging to interface with EV drive systems. This work proposes a unique topology implementing a non-isolated high step-up DC-DC converter to integrate the Proton Exchange Membrane Fuel (PEMF) cell with the EV motor drive.

Harnessing insects mediated plastic biodegradation: Current insight and future directions.

Plastic polymers pose a significant challenge due to their resistance to degradation, resulting in their persistent accumulation in the environment and exacerbating a critical environmental concern. Urgent innovation and novel management technologies are essential to tackle this issue. Plastic biodegradation, distinguished by its environmentally friendly and safe attributes, has garnered substantial attention as a viable solution.

Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state.

Current evidence suggests that ontogeny may account for the functional heterogeneity of some tissue macrophages, but not others. Here, we asked whether developmental origin drives different functions of skin Langerhans cells (LCs), an embryo-derived mononuclear phagocyte with features of both tissue macrophages and dendritic cells. Using time-course analyses, bone marrow chimeras, and fate tracing models, we found that the complete elimination of embryo-derived LCs at steady state results in their repopulation from circulating monocytes.

β-1,3-glucan from : a promising epidrug targeting epigenetic regulators PRMTs and SIRTs for therapeutic applications in ovarian cancer.

Natural products serve as a valuable resource in drug discovery and the identification of bioactive molecules in the field of epimedicine, which targets epigenetic regulator enzymes through epidrugs. In this study, β-1,3-glucan (BG), a natural storage polysaccharide in a well-known immunostimulatory agent, is propounded as a promising epidrug. To elucidate the therapeutic efficacy of BG against ovarian cancer, the molecular interactions between BG and epigenetic regulators, Protein Arginine Methyltransferases (PRMTs) and Sirtuins (SIRTs) were investigated using computational methods followed by gene expression studies in SKOV-3 ovarian cancer cell line.

Effects of Inosine-5'-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on Growth in Standard and Modified Culture Conditions.

's inosine-5'-monophosphate dehydrogenase (IMPDH, GuaB encoded by the gene) is a potential therapeutic target. GuaB is necessary for replication in mammalian hosts but not in standard laboratory culture conditions. Therefore, we cannot test novel GuaB inhibitors against without utilizing mammalian infection models.

Comparative Assessment of Compomers and Ormocers as Pit and Fissure Sealants in Permanent Molars among Children Aged 7-9 Years.

Introduction: In recent years, the dental profession's focus has shifted from the therapeutic to the preventive aspect of dental caries. Pit and fissure sealants, optimal fluoridation, healthy dietary habits, and good oral hygiene have been recommended for caries prevention. Many sealant materials are available on the market.

Beyond Nyquist: A Comparative Analysis of 3D Deep Learning Models Enhancing MRI Resolution.

High-spatial resolution MRI produces abundant structural information, enabling highly accurate clinical diagnosis and image-guided therapeutics. However, the acquisition of high-spatial resolution MRI data typically can come at the expense of less spatial coverage, lower signal-to-noise ratio (SNR), and longer scan time due to physical, physiological and hardware limitations. In order to overcome these limitations, super-resolution MRI deep-learning-based techniques can be utilised.

Emerging therapeutic and diagnostic strategies for coronary artery disease: Current trends and future perspectives.

Coronary vascular disease (CVD) is the general term used to cover conditions like narrowed blood vessels that may cause stroke or heart attack. Coronary artery disease (CAD) is one of the CVD and it is the most severe disease worldwide. The traditional treatment for CAD includes Coronary Artery Bypass Graft Surgery (CABG) and Percutaneous Coronary Intervention (PCI).

Clinical, Etiological, and Imaging Study of Patients with Cerebral Sinus Venous Thrombosis in a Tertiary Care Hospital.

Aim Of The Study: To study the clinical profile, etiology, and imaging features of subjects presenting with cerebral sinus venous thrombosis (CVST) and to correlate the clinical findings with radiological findings.

Materials And Methods: The study included 120 patients admitted with the diagnosis of CVST to Stanley Medical College and Hospital, Chennai. The study included patients of all age-groups presenting with cerebral venous thrombosis.

Marker-assisted introgression to improve the oleic acid content in the TMV 7 groundnut (Arachis hypogaea L.) variety suitable for the oil industry.

Background: Improving the quality and shelf life of groundnut oil is one of the foremost objectives of groundnut breeding programmes. This can be achieved by marker-assisted introgression, a technique that efficiently and precisely enables breeders to develop plants with enhanced qualities. This study focused on improving the oleic acid content of an elite groundnut variety, TMV 7, by introgressing a recessive mutation responsible for the increase in oleic acid from ICG 15419.

Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: A randomized clinical trial.

Background: Subgingival bacterial colonization and biofilm formation are known to be the main etiology of periodontal disease progression. This biofilm elicits host response and the interaction between host defence mechanisms with plaque microorganisms and their products results in periodontal disease. Host modulatory therapy (HMT) is a form of treatment of periodontitis that focuses on treatment of the host in the host-bacteria interaction.

Outcomes of Endovascular Aneurysm Repair (EVAR) Compared to Open Repair in Abdominal Aortic Aneurysm: An Umbrella Meta-Analysis.

This umbrella meta-analysis aims to investigate two surgical treatments for abdominal aortic aneurysm (AAA): endovascular aneurysm repair (EVAR) and open surgery repair (OSR). Our study aims to elucidate the 30-day mortality rate, reintervention rates, and aneurysm-related mortality in EVAR versus OSR for AAA.  We conducted a comprehensive assessment of meta-analyses ( = 34 articles) comparing EVAR and OSR for AAA.