Anatomy is a vital discipline in the realm of Medicine, and its primary means of study is through the use of cadavers. Experts in the medical, legal, and ethical domains have discussed the use of cadavers or their anatomical parts for educational purposes, which are considered a severe drawback. The advantages of using cadavers include their contribution to medical education, research, the investigation of innovative surgical procedures or techniques, the detection of anatomical differences at an individual or population level, the enhancement of surgical skills, and the support of other anatomical investigations.
View Article and Find Full Text PDFDiabetes mellitus has a global impact affecting 422 million individuals and leading to significant health complications. This makes it a pressing global health concern. Present treatments prioritize alleviating symptoms; however, it is imperative to adopt a multitarget strategy.
View Article and Find Full Text PDFNephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to explore the ability of in preventing AlCl3 and D-Galactose-induced nephrotoxicity in rats.
View Article and Find Full Text PDFBiomedicines
September 2021
Neurotransmission and cognitive dysfunctions have been linked to old age disorders including Alzheimer's disease (AD). Aluminium is a known neurotoxic metal, whereas d-galactose (d-gal) has been established as a senescence agent. WIN55,212-2 (WIN), is a potent cannabinoid agonist which partially restores neurogenesis in aged rats.
View Article and Find Full Text PDFBackground: Cannabis and its extracts are now being explored due to their huge health benefits. Although, the effect they elicit, whether on humans or rodents, may vary based on the age of the animal/subject and or the time in which the extract is administered. However, several debates exist concerning the various medical applications of these compounds.
View Article and Find Full Text PDFDrought is increasing prevalently, mostly due to global warming, and harmful effects associated with drought stress include a reduction in the developmental phases of the plant life cycle. Drought stress affects vital metabolic processes in plants such as transpiration, photosynthesis and respiration. The other physiological and cellular processes like protein denaturation and aggregation are also affected by drought.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant (CA) is renowned for its nutritional benefits and herbal formulas for promoting health, enhancing cognition, and its neuroprotective effects. The present study aims to investigate the protective role of CA on D-gal/AlCl₃-induced cognitive deficits in rats.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a neurodegenerative disorder and the commonest cause of dementia among the aged people. -galactose (D-gal) is a senescence agent, while aluminium is a known neurotoxin linked to pathogenesis of AD. The combined administration of rats with d-gal and aluminium chloride (AlCl) is considered to be an easy and a cheap method to obtain an animal model of AD.
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