Inhibition of steryl sulfatase activity in LNCaP human prostate cancer cells.

The enzyme steryl sulfatase may help support the growth of hormone-dependent tumors, including prostate cancers, by facilitating the conversion of circulating precursor steroids to active hormones. We sought to determine the presence of steryl sulfatase activity in the androgen-dependent human prostate cancer cell line LNCaP, and to determine if this activity was inhibited by known steryl sulfatase inhibitors. Intact LNCaP cultures had steryl sulfatase activity, as determined by conversion of [3H]estrone sulfate (E(1)S) to unconjugated steroids.

Steroid sulfatase activity in the rat ovary, cultured granulosa cells, and a granulosa cell line.

Direct production of gonadal steroids from sulfated adrenal androgens may be an important alternative or complementary pathway for ovarian steroidogenesis. The conversion of sulfated adrenal androgens, present in serum at micromolar concentrations in adult women, into unconjugated androgens or estrogens requires steroid sulfatase (STS) activity. STS activity has not been characterized in the rat ovary.

[Pregnancy and labor in patients with myopathy].

25 years old pregnant women with dysrtophia musculorum progresiva was observed in The Ludwik Rydygier Medical University in Bydgoszcz (Poland). Pre-term activity of uterus and diabetes gravidarum were complicated pregnancy. In 36 week of pregnancy forceps operation was make of obstetric indications and maternal myopathy.

[The course of pregnancy and delivery among women with thrombocytopenia].

Between January 1987 and December 1997 in The Ludwik Rydygier Medical University in Bydgoszcz 10 pregnant woman with autoimmune or "gestational" thrombocytopenia and preeclampsia--associated thrombocytopenia were evaluated. All of the patients delivered naturally and one delivered by caesarean section for obstetric indications. Severe neonatal thrombocytopenia was observed in one of newborns.

[Evaluation of ovarian tumor vascularization by means of intravaginal ultrasonography with color Doppler].

53 cases of ovarian tumors were diagnosed and operated in the Clinic of Obstetrics and Gynecology of Medical Academy in Bydgoszcz in years 1996-1997. Retrospective analysis of 58 results of ultrasonographic examination with color-Doppler estimated flows and histopathological diagnoses in cases of ovarian tumor was performed. On the ground of sonographically estimated morphology, presence or absence of vascularization and pulsation and resistance indices (PI and RI respectively) an attempt to discriminate benign and malignant tumors was made.

[Struma ovarii: rare ovarian neoplasm].

Authors of this research present 3 cases of struma ovarii diagnosed in postoperative histopathological examination in years 1994-1997. The first one was accidentally discovered during examination of a woman in menopausal period, the second was a case of 39-years old woman with hyperthyroidism and struma parenchymatoso-nodosa and the third was detected during examination of a young 21-years old woman with abdominal pain. In first two cases Doppler flowmetry revealed low RI and PI parameters (< 0.

[Fertility of women after surgical intervention on organs of reproduction].

The research included 114 female patients treated at the Clinic of Obstetrics and Gynaecology in the years 1986-1991. Information was based on a questionnaire, with 40 (35%) answers. Basic parameters of fertility were evaluated in women, who underwent surgical intervention on reproductive organs and they were discussed in connection with other conditioning.