Publications by authors named "Saranya Thawanaphong"

Article Synopsis
  • The study analyzed human tissue biopsies from healthy gums, gingivitis, and periodontitis to examine the types of B cells present in different periodontal conditions.
  • The findings revealed that during periodontitis, plasma cells (CD19(+)CD27(+)CD38(+)CD138(+)HLA-DR(low)) were the predominant B cell type, particularly located at the base of periodontal pockets, unlike in healthy tissue where memory B cells were more common.
  • Pro-inflammatory molecules that promote B cell activity were found in higher levels in gingivitis and periodontitis tissues, indicating that these conditions foster an immune response largely directed against periodontal pathogens.
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Background: A disintegrin and metalloproteinase 8 (ADAM8) is involved in inflammation and is essential for osteoclastogenesis. Elevated ADAM8 levels are detected in human serum and other body fluids in several inflammatory conditions. Therefore, we hypothesized that ADAM8 levels are also raised in gingival crevicular fluid (GCF) of patients with periodontal diseases.

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Infantile malignant autosomal recessive osteopetrosis (ARO; OMIM 259700) has been reported to be associated with mutations in TCIRG1, CLCN7, or OSTM1. ARO caused by homozygous (or compound heterozygous) mutations in CLCN7, as described here, is usually diagnosed at birth or early in infancy due to generalized osteosclerosis and severe hematologic deficits. The maximal life expectancy of patients with ARO in the absence of bone marrow transplantation is thought to be 10 years.

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