Regional and temporal variability of Indian summer monsoon rainfall in relation to El Niño southern oscillation.

The Indian summer monsoon rainfall (ISMR) exhibits significant variability, affecting the food and water security of the densely populated Indian subcontinent. The two dominant spatial modes of ISMR variability are associated with the El Niño Southern Oscillation (ENSO) and the strength of the semi-permanent monsoon trough along with related variability in monsoon depressions, respectively. Although the robust teleconnection between ENSO and ISMR has been well established for several decades, the major drivers leading to the time-varying relationship between ENSO and ISMR patterns across different regions of the country are not well understood.

De-novo exposure assessment of heavy metals in commercially important fresh and dried seafood: Safe for human consumption.

The heavy metals (HMs) in seafood are alarming due to their biomagnification in the food chain. The concentrations of As, Cd, Hg, Pb, Cr, and Ni in both fresh and dried fish were quantified, and the potential exposure and safe intake levels for human consumption were assessed by the European Commission (EC) and the Food Safety Standard Authority of India (FSSAI). HMs concentrations ranged from 0.

Biophysical insights on the interaction of anticoagulant drug dicoumarol with calf thymus-DNA: deciphering the binding mode and binding force with thermodynamics.

The biological activity of drugs is exhibited due to their interactions with bio-receptors. Dicoumarol (DIC) is a natural hydroxycoumarin and a well-known anticoagulant. DNA is the genetic material and one of the targets of numerous drugs.

Cerium Oxide/Graphene Oxide Hybrid: Synthesis, Characterization, and Evaluation of Anticancer Activity in a Breast Cancer Cell Line (MCF-7).

In the present study, we used a simple ultrasonic approach to develop a Cerium oxide/Graphene oxide hybrid (CeO/GO hybrid) nanocomposite system. Particle size analysis, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray Diffraction (XRD) have been used to analyze the physio-chemical characteristics of the developed nanocomposite. The synthesized hybrid system has also been examined to assess its anticancer capability against MCF-7 cell lines and normal cell lines at different sample concentrations, pH values, and incubation intervals using an antiproliferative assay test.

CdO nanoparticles, c-MWCNT nanoparticles and CdO nanoparticles/c-MWCNT nanocomposite fibres: in vitro assessment of anti-proliferative and apoptotic studies in HeLa cancer cell line.

A simple ultrasonic assisted chemical technique was used to synthesise cadmium oxide (CdO) nanoparticles (NPs) and CdO NPs/c-Multiwalled carbon nanotube (c-MWCNT) nanocomposite fibres.To confirm the physio-chemico properties and to analyse surface morphology of the obtained nanomaterials X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM) were performed. To evaluate the anti-cancer property of CdO NPs, c-MWCNT NPs and CdO NPs/c-MWCNT nanocomposite fibres, an anti-proliferative assay test (Methylthiazolyl diphenyl- tetrazolium bromide - MTT assay) were performed on HeLa cells which further estimated IC50 value (Least concentration of sample in which nearly 50% of cells remain alive) under in-vitro conditions.

Effects of a new synthetic zerumbone pendant derivative (ZPD) on apoptosis induction and anti-migratory effects in human cervical cancer cells.

A newly synthesised zerumbone pendant derivative (ZPD) was studied in human cervical cancer cells (HeLa) for its anticancer properties. ZPD significantly inhibited the growth of human cervical cancer cells with a GI value of 6.35 ± 1.

Leaf Lectin (MLL) Sensitizes MCF-7 Cells to Anoikis by Inhibiting Fibronectin Mediated Integrin-FAK Signaling through Ras and Activation of P MAPK.

Lectins are a unique class of carbohydrate binding proteins/glycoproteins, and many of them possess anticancer properties. They can induce cell cycle arrest and apoptosis, inhibit protein synthesis, telomerase activity and angiogenesis in cancer cells. In the present study, we have demonstrated the effect of leaf lectin (MLL) on anoikis induction in MCF-7 cells.

Corrosion inhibition property of polyester-groundnut shell biodegradable composite.

The use of natural fibers as reinforcing materials in thermoplastics and thermoset matrix composites provide optimistic environmental profits with regard to ultimate disposability and better use of raw materials. The present work is focused on the corrosion inhibition property of a polymer matrix composite produced by the use of groundnut shell (GNS) waste. Polyester (PE) was synthesized by condensation polymerization of symmetrical 1,3,4-oxadiazole and pimelic acid using sodium lauryl sulfate as surfactant.

Anticancer activity of synthetic bis(indolyl)methane-ortho-biaryls against human cervical cancer (HeLa) cells.

Bis(indolyl)methane appended biaryls were designed, synthesized and evaluated in human cervical cancer cell lines (HeLa) for their anticancer activities and compared against normal rat cardiac myoblasts (H9C2) cells. Compounds 1-12 were synthesized, with variations in one of the phenyl unit, in a single step by condensation of biaryl-2-carbaldehydes with indole in the presence of para-toluenesulfonic acid. Compound 1 exhibited a GI50 value of 11.