Publications by authors named "Saranya Chandrasekar"
Article Synopsis
- African Americans are more susceptible to chronic kidney disease (CKD) partly due to high-risk variants in the APOL1 gene, specifically G1/G2 variants, but a different variant, p.N264K, appears to lower this risk significantly.
- A study of over 121,000 participants showed that those with the p.N264K variant had CKD and end-stage kidney disease (ESKD) risks comparable to individuals with low-risk APOL1 variants.
- Research indicates that p.N264K blocks harmful pore-forming functions of APOL1 high-risk variants, suggesting that drugs mimicking this protective mutation could potentially prevent or treat kidney disease related to APOL1.
Potato ( L.) is an important food crop worldwide, and potato cyst nematodes (PCNs) are among the most serious pests. The identification of disease resistance genes and molecular markers for PCN infestation can aid in crop improvement research programs against PCN infestation.
View Article and Find Full Text PDFThe actin crosslinking protein filamin A (FLNa) mediates mechanotransduction, a conversion of mechanical forces into cellular biochemical signals to regulate cell growth and survival. To provide more quantitative insight into this process, we report results using magnetic tweezers that relate mechanical force to conformational changes of FLNa immunoglobulin-like repeats (IgFLNa) 20-21, previously identified as a mechanosensing domain. We determined the force magnitudes required to unfold previously identified structural organizations of the β-strands in the two domains: IgFLNa 20 unfolds at ~15 pN and IgFLNa 21 unfolding requires significantly larger forces.
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