Zbtb1 controls NKp46 ROR-gamma-T innate lymphoid cell (ILC3) development.

Innate lymphoid cells (ILCs) play a central role conferring protection at the mucosal frontier. In this study, we have identified a requirement of the transcription factor Zbtb1 for the development of RORγt ILCs (ILC3s). Zbtb1-deficient mice lacked NKp46 ILC3 cells in the lamina propria of the small and large intestine.