Publications by authors named "Sarang Choi"
Objective: The primary objective of this study was to investigate the role and regulatory mechanisms of platelet-derived growth factor subunit B (PDGFB) in muscle differentiation.
Methods: In this study, a vector for PDGFB was designed and transfected into quail muscle cells to investigate its role and regulatory mechanism during muscle formation. To investigate the inhibitory mechanisms of PDGFB on myogenic differentiation, the mRNA expression levels of various genes and the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2), both known to regulate muscle development and differentiation were compared.
Sarcopenia refers to an age-related reduction of lean body mass. It showed a reciprocal relationship with cardiovascular diseases. Thus, it is imperative to explore pathophysiological mechanisms explaining the relationship between sarcopenia and cardiovascular diseases, along with the clinical assessment, and associated management.
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- * Both NAFLD and sarcopenia share risk factors and mechanisms, including insulin resistance, systemic inflammation, hormonal changes, and liver dysfunction-related factors.
- * The review discusses how addressing these interconnected conditions through lifestyle changes (like diet and exercise) and medical treatments (like specific supplements and therapies) can help manage and improve patient outcomes.
Heart failure (HF) is a chronic, debilitating condition associated with significant morbidity, mortality, and socioeconomic burden. Patients with end-stage HF (ESHF) who are not a candidate for advanced therapies will continue to progress despite standard medical therapy. Thus, the focus of care shifts from prolonging life to controlling symptoms and improving quality of life through palliative care ().
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- Systemic lupus erythematosus (SLE) is a serious autoimmune disease capable of impacting multiple organs, with potentially fatal complications like lupus cerebritis and lupus nephritis.
- A case of a 23-year-old female showed extreme symptoms including high-grade fever, seizures, and lymphadenopathy, leading to diagnoses linked with severe SLE manifestations.
- Although she received treatment that provided some symptom relief, she ultimately did not survive, highlighting the significance of recognizing unusual symptoms like generalized lymphadenopathy in diagnosing SLE.