Comparison of immunogenicity of adjuvanted and high dose influenza vaccination in long-term care facility residents.

Background: The CDC recommends the more immunogenic adjuvanted and high-dose flu vaccines over standard-dose, non-adjuvanted vaccines for individuals above 65 years old. The current study compares adjuvanted trivalent inactivated flu vaccine (aTIV, FLUAD) versus high-dose flu vaccine (HD-IIV3, FLUZONE HD) to determine if they met non-inferiority standards for older long-term care facility (LTCF) residents.

Methods: We collected blood from long-term care facility residents participating in a randomized 1:1 active control trial comparing MF59C.