Publications by authors named "Sarah Z Wang"
Introduction: Primary hyperparathyroidism (PHPT) is more prevalent in populations with obesity. Obesity-related vitamin D deficiency may affect rates of multigland parathyroid disease, but this relationship is less clear. We aimed to assess the relationship between obesity and the rate of multigland disease in patients with PHPT.
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- Robotic surgery (RDN) for kidney donation results in less tissue manipulation and faster recovery compared to open mini-incision surgery (ODN).
- A study comparing 141 RDN cases to 191 ODN cases found that RDN led to significantly less blood loss and a shorter hospital stay.
- Overall complication rates were low for both methods, indicating that RDN offers advantages without increasing risks.
Background: Selection of central venous catheter (CVC) lock solution impacts catheter mechanical complications and central line-associated bloodstream infections (CLABSIs) in pediatric patients with intestinal failure. Disadvantages of the current clinical standards, heparin and ethanol lock therapy (ELT), led to the discovery of new lock solutions. High-risk pediatric patients with intestinal failure who lost access to ELT during a recent shortage were offered enrollment in a compassionate use trial with 4% tetrasodium EDTA (T-EDTA), a lock solution with antimicrobial, antibiofilm, and antithrombotic properties.
View Article and Find Full Text PDFFat malabsorption is central to the pathophysiology of short bowel syndrome (SBS). It occurs in patients with insufficient intestinal surface area and/or function to maintain metabolic and growth demands. Rapid intestinal transit and impaired bile acid recycling further contribute to fat malabsorption.
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- Neonates with congenital diaphragmatic hernia (CDH) often need cardiopulmonary bypass and anticoagulation therapy, but previous studies showed that even low doses of heparin can hinder lung growth and function.
- In an experiment on mice, heparin alone reduced lung endothelial cell proliferation and increased cell death, but the negative effects on proliferation could be mitigated with direct thrombin inhibitors (DTIs) like bivalirudin and argatroban.
- Despite these promising findings in vitro, the study concluded that DTIs did not sufficiently counteract the decreased lung growth associated with low-dose heparin in vivo, highlighting the need for clinical research on the combined effects of heparin and DTIs in