Publications by authors named "Sarah Yousuf"
Blind But Alive - Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish.
Invest Ophthalmol Vis Sci
November 2024
Article Synopsis
- The study focuses on adult zebrafish that are blind due to mutations in the atoh7 gene, which prevents the formation of retinal ganglion cells (RGCs).
- Researchers characterized the physical and behavioral traits of these mutants using various scientific techniques, noting distinct characteristics like dark pigmentation and reduced body size.
- The findings highlight that these adult zebrafish serve as a valuable model for studying conditions like glaucoma and optic nerve aplasia by providing insights into retinal and tectal structure.
Background: Increased epidermal growth factor receptor (EGFR) expression has been implicated in several tumors and is associated with increased tumor advancement as well as a potential drug target. The objective of the study was to compare the immunohistochemical expression of EGFR in oral squamous cell carcinoma (OSCC) with oral potentially malignant disorders (OPMDs) and their demographic and pathologic parameters.
Methods: This study was a comparative cross-sectional analytical study.
Visual Function is Gradually Restored During Retina Regeneration in Adult Zebrafish.
Front Cell Dev Biol
February 2022
In comparison to mammals, zebrafish are able to regenerate many organs and tissues, including the central nervous system (CNS). Within the CNS-derived neural retina, light lesions result in a loss of photoreceptors and the subsequent activation of Müller glia, the retinal stem cells. Müller glia-derived progenitors differentiate and eventually restore the anatomical tissue architecture within 4 weeks.
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