Publications by authors named "Sarah W Marion"
Article Synopsis
- Transcription factor HLH-30/TFEB regulates autophagy, and silencing the nuclear export protein XPO-1/XPO1 enhances autophagy by keeping HLH-30 in the nucleus.
- This increase in autophagy leads to advantages like better proteostasis and longer lifespan in C. elegans, requiring both HLH-30 and autophagy.
- The study suggests that inhibiting XPO1 can boost autophagy and potentially protect against neurodegeneration, indicating a conserved mechanism across different cell types.
