Malic Enzyme 1 (ME1) is pro-oncogenic in Apc mice.

Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc mice to obtain male Apc/ME1-Tg mice. ME1 protein levels were significantly greater within gut epithelium and adenomas of male Apc/ME1-Tg than Apc mice.

Limited utility of routine surveillance imaging for classical Hodgkin lymphoma patients in first complete remission.

Background: The objective of this study was to compare the outcomes of patients with classical Hodgkin lymphoma (cHL) who achieved complete remission with frontline therapy and then underwent either clinical surveillance or routine surveillance imaging.

Methods: In total, 241 patients who were newly diagnosed with cHL between January 2000 and December 2010 at 3 participating tertiary care centers and achieved complete remission after first-line therapy were retrospectively analyzed. Of these, there were 174 patients in the routine surveillance imaging group and 67 patients in the clinical surveillance group, based on the intended mode of surveillance.