Publications by authors named "Sarah Vandelanotte"
Thrombolytic therapies for acute ischemic stroke are widely available but only result in recanalization early enough, to be therapeutically useful, in 10% to 30% of cases. This large gap in treatment effectiveness could be filled by novel therapies that can increase the effectiveness of thrombus clearance without significantly increasing the risk of harm. This focused update will describe the current state of emerging adjuvant treatments for acute ischemic stroke reperfusion.
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- Achieving first-pass recanalization (FPR) during thrombectomy is crucial for better clinical outcomes in acute ischemic stroke patients, making it important to understand the factors that cause FPR failures.
- This study examined the relationship between thrombus composition and the success rates of FPR by analyzing thrombi from 267 stroke patients.
- Results showed that thrombi leading to successful FPR had more red blood cells and less fibrin and extracellular DNA, suggesting that certain thrombus characteristics can influence the likelihood of achieving FPR.
Article Synopsis
- Researchers studied how the composition of blood clots (thrombi) affects their breakdown by r-tPA, a treatment for acute ischemic stroke.
- They found that thrombi with more red blood cells are easier to dissolve than those with higher levels of DNA and von Willebrand Factor.
- Adding DNase-1 or N,N'-diacetyl-l-cystine to r-tPA treatments significantly improved the breakdown of harder-to-treat thrombi.
Ischemic stroke is caused by a thrombus blocking one or multiple arteries in the brain, resulting in irreversible damage in the associated brain tissue. The aim of therapy is to restore the blood flow as fast as possible. Two recanalization strategies are currently available: pharmacological thrombolysis using recombinant tissue plasminogen activator (rt-PA) and mechanical removal of the thrombus.
View Article and Find Full Text PDFBackground: Several studies have investigated the histopathology of mechanically retrieved thrombi from stroke patients. Thrombi with unusual components constitute about 1-2% of all stroke thrombi in clinical practice. Knowledge about these rare components is limited.
View Article and Find Full Text PDFHazardous alcohol use is one of the leading risk factors for morbidity and mortality in the world. Early identification and brief interventions (EIBIs) delivered in primary care is an effective but underutilized strategy to address this issue. Community-oriented strategies (COS) are suggested to facilitate EIBI delivery.
View Article and Find Full Text PDFBackground: Hazardous alcohol use significantly affects health and wellbeing in society. General practitioners (GPs) are uniquely positioned to address this problem by integrating early identification and brief intervention (EIBI) in daily practice. Unfortunately, EIBI implementation remains low.
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