Publications by authors named "Sarah Toepfer"
Article Synopsis
- A study explored the link between lipoprotein(a) [Lp(a)] levels and lung function in 679 relatively healthy older adults, finding that higher Lp(a) levels correlated with better lung function parameters.
- Despite the initial findings indicating a positive association between Lp(a) and lung function, these results were not confirmed by Mendelian randomization analyses that utilized recent genome-wide study data.
- The researchers suggest further investigation is needed due to the significant and possibly clinically relevant differences observed in lung function related to Lp(a) levels.
Genetic variants in UMOD associate with kidney function and hypertension. These phenotypes are also linked to sex-related differences and impairment in cognitive and physical function in older age. Here we evaluate longitudinal associations between a common UMOD rs4293393-A>G variant and changes in estimated glomerular filtration rate (eGFR), blood pressure (BP), cognitive and physical function parameters in older participants in the BASE-II after long-term follow-up as part of the GendAge study.
View Article and Find Full Text PDFIn genome-wide association studies, genetic variants in the UMOD gene associate with kidney function, blood pressure (BP), and hypertension. Elevated BP is linked to kidney function and impaired cognitive as well as physical performance in later life. We investigated the association between UMOD rs4293393-A > G and kidney function, BP, cognitive and physical function in the Berlin Aging Study II (BASE-II).
View Article and Find Full Text PDFIntroduction: Medication safety is a vital aim in older adults' pharmacotherapy. Increased morbidity and vulnerability require particularly careful prescribing. Beneath avoiding unnecessary polypharmacy and prescribing omissions, physicians have to be aware of potentially inappropriate medications (PIMs) and related outcomes to optimize older adults' drug therapy, and to reduce adverse drug events.
View Article and Find Full Text PDFIt has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the cross-sectional data of 1,380 Berlin Aging Study II (BASE-II) participants aged 60 years and older (52.
View Article and Find Full Text PDFIntroduction: Multimorbidity in advanced age and the need for drug treatment may lead to polypharmacy, while pharmacokinetic and pharmacodynamic changes may increase the risk of adverse drug events (ADEs).
Objective: The aim of this study was to determine the proportion of subjects using potentially inappropriate medication (PIM) in a cohort of older and predominantly healthy adults in relation to polypharmacy and morbidity.
Methods: Cross-sectional data were available from 1,382 study participants (median age 69 years, IQR 67-71, 51.