Publications by authors named "Sarah Tasneem"
Article Synopsis
- The study investigates the effects of mixing fluoxetine, an antidepressant, with midazolam, a sedative, over repeated use.
- It measures various behavioral responses and neurochemical changes in rats after 12 days of treatment, including motor activity and brain chemistry related to dopamine and serotonin.
- Results indicate that fluoxetine reduces the reinforcing effects of midazolam, which could enhance the therapeutic benefits of midazolam while potentially reducing its abuse potential.
In the present study we have monitored dose dependent effects of midazolam; a benzodiazepine (CNS depressant). It is the primary drug of choice for procedural sedation, preoperative sedation, and in emergency departments. Repeated administration of this drug is reported to have abuse potential and may cause this by increasing dopaminergic neurotransmission.
View Article and Find Full Text PDFSmall Ubiquitin-like Modifier (SUMO) is a ∼10 kDa peptide that can be post-translationally added to a lysine (K) on a target protein to facilitate protein-protein interactions. Recent studies have found that SUMOylation can be regulated in an activity-dependent manner and that ion channel SUMOylation can alter the biophysical properties and surface expression of the channel. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression can be regulated in an activity-dependent manner through unknown processes.
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