Clinicopathological correlates of depression in early Alzheimer's disease in the NACC.

Objective: Depression may be a prodrome to Alzheimer's disease (AD). We assessed whether AD neuropathology is associated with depression in mild cognitive impairment (MCI) and mild dementia (dAD).

Methods: All clinical and neuropathological data for this study came from the National Alzheimer's Coordinating Center (NACC).