The association between familial death in childhood or adolescence and subsequent substance use disorder: A systematic review and meta-analysis.

Background: Exposure to childhood adversity has been linked to long-term negative mental health consequences in adulthood.

Purpose: This review examined the association between exposure to the death of a family member (i.e.

A meta-analysis of the relationship between parental death in childhood and subsequent psychiatric disorder.

Objective: To systematically review evidence for an association between parental death in childhood, and the subsequent development of an anxiety, affective or psychotic disorder.

Methods: Electronic databases (Scopus, Medline (for Ovid), EMBASE and PsychINFO) were searched for peer-reviewed, cohort studies in the English language. Meta-analyses were performed for studies reporting hazard ratios, incidence rate ratios and odds ratios.