Publications by authors named "Sarah Stengel"
Article Synopsis
- - Disease tolerance is a vital survival strategy that minimizes physical damage from infections without directly killing the pathogens, and this tolerance shifts as an organism ages.
- - Research using a polymicrobial sepsis model revealed distinct health responses in young and old mice after infection, highlighting different disease courses related to their age.
- - Young mice utilized a protective mechanism involving FoxO1 that helped them survive, while the same mechanism contributed to heart issues and death in older mice, underscoring the need for age-specific therapy in infections.
Infect Immun
September 2022
Article Synopsis
- Hosts utilize both aggressive and cooperative strategies to defend against infections, with Leptin playing a key role in resistance mechanisms but its impact on cooperation with pathogens not fully understood.
- In a study on mice infected with Yersinia pseudotuberculosis, a lack of Leptin signaling resulted in increased cooperation between the host and pathogen, leading to protection against infection, though it wasn't due to resistance or changes in energy metabolism.
- The findings suggest that in certain situations, it may be more advantageous for hosts to tolerate organ damage caused by infection rather than solely focusing on preventing damage or killing the pathogen.
