Publications by authors named "Sarah Si Kai Tan"
Article Synopsis
- Polysorbates 20 and 80 are commonly used in biopharmaceuticals to stabilize proteins, but they degrade easily, leading to issues like protein oxidation and aggregation that compromise product quality.
- KLEPTOSE HPβCD, a new excipient, shows superior stability under stress conditions compared to polysorbates, maintaining high recovery rates and resisting degradation from heat, light, and chemical exposure.
- The study highlights that while polysorbates degrade significantly when stressed, HPβCD retains its chemical structure and provides better physicochemical stability for therapeutic proteins, making it a promising alternative in biologic formulations.
