Publications by authors named "Sarah Schimmelpfennig"
Article Synopsis
- In T lymphocytes, miR-148a is promoted by T-bet and Twist1, specifically in pro-inflammatory Th1 cells, where it helps prevent apoptosis by inhibiting the Bim protein.
- Using antagomir-148a, researchers successfully reduced Th1 cell numbers in a colitis model by 50% and increased Bim expression, leading to significant improvement in colitis.
- The treatment selectively targeted chronic inflammation without affecting antigen-specific memory T cells or their antibody responses, suggesting it could be a potential therapy for chronic inflammatory conditions.
