The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data.

The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal ( https://data.4dnucleome.

Replication and partitioning of the apicoplast genome of Toxoplasma gondii is linked to the cell cycle and requires DNA polymerase and gyrase.

Apicomplexans are the causative agents of numerous important infectious diseases including malaria and toxoplasmosis. Most of them harbour a chloroplast-like organelle called the apicoplast that is essential for the parasites' metabolism and survival. While most apicoplast proteins are nuclear encoded, the organelle also maintains its own genome, a 35 kb circle.

Aurora kinase inhibitors delay regeneration in at an intermediate step.

The giant unicellular ciliate Stentor coeruleus can be cut into pieces and each piece will regenerate into a healthy, full-sized individual. The molecular mechanism for how Stentor regenerates is a complete mystery, however, the process of regeneration shows striking similarities to the process of cell division. On a morphological level, the process of creating a second mouth in division or a new oral apparatus in regeneration have the same steps and occur in the same order.

The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell.

The giant, single-celled organism Stentor coeruleus has a long history as a model system for studying pattern formation and regeneration in single cells. Stentor [1, 2] is a heterotrichous ciliate distantly related to familiar ciliate models, such as Tetrahymena or Paramecium. The primary distinguishing feature of Stentor is its incredible size: a single cell is 1 mm long.

Radiation-Induced Chemical Changes to Iron Oxides.

The radiolysis of a variety of iron oxide powders with different amounts of associated water has been performed using γ rays and 5 MeV (4)He ions. Adsorbed water was characterized by both temperature-programmed desorption and diffuse reflection infrared Fourier transform spectroscopy to reveal a variety of active sites on the surface. Molecular hydrogen production was found only from water adsorbed on Fe2O3, and the yield was several orders of magnitude greater than that of bulk water.

The HU protein is important for apicoplast genome maintenance and inheritance in Toxoplasma gondii.

The apicoplast, a chloroplast-like organelle, is an essential cellular component of most apicomplexan parasites, including Plasmodium and Toxoplasma. The apicoplast maintains its own genome, a 35-kb DNA molecule that largely encodes proteins required for organellar transcription and translation. Interference with apicoplast genome maintenance and function is a validated target for drug therapy for malaria and toxoplasmosis.

A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii.

Background: Apicomplexan parasites cause numerous important human diseases, including malaria and toxoplasmosis. Apicomplexa belong to the Alveolata, a group that also includes ciliates and dinoflagellates. Apicomplexa retain a plastid organelle (the apicoplast) that was derived from an endosymbiotic relationship between the alveolate ancestor and a red alga.

Building the perfect parasite: cell division in apicomplexa.

Apicomplexans are pathogens responsible for malaria, toxoplasmosis, and crytposporidiosis in humans, and a wide range of livestock diseases. These unicellular eukaryotes are stealthy invaders, sheltering from the immune response in the cells of their hosts, while at the same time tapping into these cells as source of nutrients. The complexity and beauty of the structures formed during their intracellular development have made apicomplexans the darling of electron microscopists.

Psychophysiological correlates of narcissistic traits in women during active coping.

Two dimensions of narcissism were related to psychophysiological responses to stress in 50 young women. Cardiovascular, electrodermal, task performance, and stress appraisal measures were recorded during rest, mental arithmetic, and a computerized Thematic Apperception Test (Murray, 1943). The Egocentricity and Alienation scales of the Bell Object Relations and Reality Testing Inventory (Bell, 1995) served as measures of overt/inflated and covert/deflated narcissism.