Automated model discovery for human brain using Constitutive Artificial Neural Networks.

The brain is our softest and most vulnerable organ, and understanding its physics is a challenging but significant task. Throughout the past decade, numerous competing models have emerged to characterize its response to mechanical loading. However, selecting the best constitutive model remains a heuristic process that strongly depends on user experience and personal preference.

Sex Matters: A Comprehensive Comparison of Female and Male Hearts.

Unlabelled: Cardiovascular disease in women remains under-diagnosed and under-treated. Recent studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic criteria. While it is widely recognized that the female heart is smaller than the male heart, it has long been ignored that it also has a different microstructural architecture.

Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.

A monolayer of highly motile cells can establish long-range orientational order, which can be explained by hydrodynamic theory of active gels and fluids. However, it is less clear how cell shape changes and rearrangement are governed when the monolayer is in mechanical equilibrium states when cell motility diminishes. In this work, we report that rat embryonic fibroblasts (REF), when confined in circular mesoscale patterns on rigid substrates, can transition from the spindle shapes to more compact morphologies.