Publications by authors named "Sarah R Simmons"
Article Synopsis
- HepB-CpG (Heplisav-B) is a hepatitis B vaccine that requires only 2 doses, while HepB-alum (Engerix-B) requires 3 doses, prompting a study to assess the safety of these vaccines regarding new immune-mediated diseases, herpes zoster, and anaphylaxis in a real-world setting.
- A cohort study followed 69,625 adults who received either vaccine between 2018 and 2019, using electronic health records to track the incidence of the specified outcomes for 13 months.
- Results showed similar rates of immune-mediated diseases between both vaccines, except for rheumatoid arthritis, which was initially higher for HepB-CpG but adjusted to show no significant difference after
Lancet Reg Health Am
May 2022
Article Synopsis
- The study evaluates the effectiveness of a third booster dose of the Pfizer-BioNTech vaccine (BNT162b2) among adults in the U.S., finding that while the effectiveness of two doses declines over time, a third dose significantly boosts protection against both SARS-CoV-2 infections and hospitalizations.
- In two doses, vaccine effectiveness against infections dropped from 85% to 49% over seven months, but the three-dose regimen exhibited 88% effectiveness against infections and 97% against hospitalization shortly after administration.
- The findings support booster recommendations as they show that a third dose provides enhanced protection compared to just two doses received months earlier.
