Publications by authors named "Sarah Pyne"
Objective: To compare costs and consequences of Early Stroke Specialist Vocational Rehabilitation (ESSVR) with usual care in working age, stroke survivors over 12 months.
Design: An economic evaluation nested within the pragmatic, multi-centre, randomised, controlled RETurn to work After stroKE (RETAKE) study.
Setting: Twenty-one English and Welsh National Health Service (NHS) hospital-based stroke units.
Background: Return-to-work is a major goal achieved by fewer than 50% stroke survivors. Evidence on how to support return-to-work is lacking.
Aims: To evaluate the clinical effectiveness of Early Stroke Specialist Vocational Rehabilitation (ESSVR) plus usual care (UC) (i.
Article Synopsis
- Acne is a common skin condition that affects women's quality of life and often leads to long-term antibiotic use, prompting the study of spironolactone as a potential treatment.
- The study was a randomized, double-blind trial assessing the effectiveness and cost-effectiveness of spironolactone for treating facial acne in women aged 18 and older, continuing their usual topical treatments.
- Results showed that among the 410 women randomized, the treatment group successfully tolerated spironolactone at increasing doses, with a focus on improvements in acne-related quality of life over a 12-week period.
Objective: To estimate the cost-effectiveness of craniotomy, compared with decompressive craniectomy (DC) in UK patients undergoing evacuation of acute subdural haematoma (ASDH).
Design: Economic evaluation undertaken using health resource use and outcome data from the 12-month multicentre, pragmatic, parallel-group, randomised, Randomised Evaluation of Surgery with Craniectomy for Patients Undergoing Evacuation-ASDH trial.
Setting: UK secondary care.
Background: Chronic subdural haematoma is a collection of 'old blood' and its breakdown products in the subdural space and predominantly affects older people. Surgical evacuation remains the mainstay in the management of symptomatic cases.
Objective: The Dex-CSDH (DEXamethasone in Chronic SubDural Haematoma) randomised trial investigated the clinical effectiveness and cost-effectiveness of dexamethasone in patients with a symptomatic chronic subdural haematoma.
Objective: This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks.
Design: Economic evaluation undertaken alongside a pragmatic, parallel, double-blind, randomised trial.
Setting: Primary and secondary healthcare, community and social media advertising.
Objective: To assess the effectiveness of oral spironolactone for acne vulgaris in adult women.
Design: Pragmatic, multicentre, phase 3, double blind, randomised controlled trial.
Setting: Primary and secondary healthcare, and advertising in the community and on social media in England and Wales.
Background: Traumatic acute subdural hematomas frequently warrant surgical evacuation by means of a craniotomy (bone flap replaced) or decompressive craniectomy (bone flap not replaced). Craniectomy may prevent intracranial hypertension, but whether it is associated with better outcomes is unclear.
Methods: We conducted a trial in which patients undergoing surgery for traumatic acute subdural hematoma were randomly assigned to undergo craniotomy or decompressive craniectomy.
The term "metacognition" describes thinking about a cognitive phenomenon or, more simply put, thinking about thinking . Metacognition involves using knowledge about one's cognitive processes to change behavior, including monitoring and controlling cognition. Metacognition is vital for learning and is often more difficult for children with neurodevelopmental concerns (e.
View Article and Find Full Text PDFPurpose: Children in middle childhood are at an increased risk for injury in pedestrian environments. This study examined whether they are capable of showing evasive action (ie, adjusting crossing speed) to avoid injury when crossing streets.
Methods: The study used a fully immersive virtual reality (VR) system interfaced with a three-dimensional movement measurement system so that the actual crossing behaviour of 7-10-year-old children under different traffic conditions could be precisely measured.
Background: The involvement of consumers and the general public in improving cancer services is an important component of health services. However, consumer involvement in cancer research is relatively unexplored. The objective of this study was to explore different ways of involving consumers in cancer research in one regional network.
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