Publications by authors named "Sarah Phoebeluc Colaiuta"
Article Synopsis
- Mitophagy is a process that helps get rid of damaged parts of cells called mitochondria, and problems with it can lead to diseases as we age.
- Researchers found that a protein called Siah3 stops mitophagy and helps mice develop their nerves in a better way.
- Mice without Siah3 showed that their nerve cells didn’t break down as quickly when they lost support, suggesting that Siah3 plays a big role in how cells manage their health and growth.
Article Synopsis
- Reciprocal communication between the brain and immune system is vital for maintaining brain function throughout life, with immune cells playing a crucial role in this interaction.
- Immune exhaustion and senescence may accelerate neurodegenerative diseases, indicating that a weakened peripheral immune system contributes to the progression of these conditions.
- Strategies to enhance peripheral immunity, such as blocking inhibitory checkpoint molecules, could harness reparative immune cells to help the brain combat neurodegeneration effectively.
The choroid plexus (CP) plays a key role in remotely controlling brain function in health, aging, and disease. Here, we report that CP epithelial cells express the brain-specific cholesterol 24-hydroxylase (CYP46A1) and that its levels are decreased under different mouse and human brain conditions, including amyloidosis, aging, and SARS-CoV-2 infection. Using primary mouse CP cell cultures, we demonstrate that the enzymatic product of CYP46A1, 24(S)-hydroxycholesterol, downregulates inflammatory transcriptomic signatures within the CP, found here to be elevated across multiple neurological conditions.
View Article and Find Full Text PDFMicroglia and monocyte-derived macrophages (MDM) are key players in dealing with Alzheimer's disease. In amyloidosis mouse models, activation of microglia was found to be TREM2 dependent. Here, using Trem25xFAD mice, we assessed whether MDM act via a TREM2-dependent pathway.
View Article and Find Full Text PDFBackground: For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenerative disease emergence and severity. Numerous studies in animal models of amyloidosis demonstrated the beneficial role of monocyte-derived macrophages in mitigating the disease, though less is known regarding tauopathy.
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