Whole genome sequencing to investigate a putative outbreak of the virulent community-associated methicillin-resistant ST93 clone in a remote Indigenous community.

We report two cases of severe pneumonia due to clone ST93 methicillin-resistant (MRSA) presenting from a remote Australian Indigenous community within a 2-week period, and the utilization of whole genome sequences to determine whether these were part of an outbreak. was isolated from 12 of 92 nasal swabs collected from 25 community households (including the two index households); one isolate was ST93. Three of five skin lesion isolates obtained at the community were ST93.

Tendon morphogenesis in the developing avian limb: plasticity of fetal tendon fibroblasts.

The differentiation and patterning of tendon fibroblasts is at present a poorly understood aspect of musculoskeletal development in the vertebrate limb. Precursors of tendon fibroblasts originate in the somatic mesoderm adjacent to the early limb bud and gradually become incorporated into the limb mesenchyme as development proceeds. It is unclear whether these progenitor cells are committed to the tendon lineage at this early stage, or whether cells become committed only as they are incorporated into a developing tendon.