Reasons for Having Unprotected Sex Among Adolescents and Young Adults Accessing Reproductive Health Services.

Introduction: Although research suggests that young people are more likely to have unprotected sex than adults, their reasons for doing so are not well-understood. Among a sample of young people accessing no-cost contraceptive services, we explored their reported reasons for having unprotected sex and their willingness to have unprotected sex in the future.

Methods: We recruited sexually active assigned female at birth youth at 10 family planning clinics in the San Francisco Bay Area (n = 212).

Sexual Assault Forensic Examiner Recruitment and Retention: Using Simulation to Teach a Trauma-Informed Interview.

Traditionally, sexual assault nurse examiner training focuses on examination skills and evidence collection. Gathering history and supporting the patient in a trauma-informed approach are equally important components of postassault care. Simulation is an established tool in healthcare education; however, there is limited research on applying simulation to the training of sexual assault nurse examiners.

An Innovative Trauma-Informed Curriculum for Sexual Assault Care.

Background: Sexual violence is a pervasive public health concern. The American Association of Colleges of Nursing recommends that nursing education comprehensively address this topic, yet nursing schools are inconsistent in doing so.

Method: An innovative, holistic curriculum that includes didactic and simulation exercises was developed to educate nurses on a trauma-informed approach to providing care for individuals who have experienced sexual violence.

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.

Mitochondrial Ca (Ca) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new ruthenium complex Ru265 that is cell-permeable, minimally toxic, and highly potent with respect to MCU inhibition. Cells treated with Ru265 show inhibited MCU activity without any effect on cytosolic Ca dynamics and mitochondrial membrane potential (ΔΨ).

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor.

We detail the synthesis and purification of a mitochondrial calcium uptake inhibitor, [(OH2)(NH3)4Ru(µ-O)Ru(NH3)4(OH2)]. The optimized synthesis of this compound commences from [Ru(NH3)5Cl]Cl2 in 1 M NH4OH in a closed container, yielding a green solution. Purification is accomplished with cation-exchange chromatography.

Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands.

Reactions of K[RuNCl(HO)] with 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (dmbpy), and 4,4'-dimethoxy-2,2'-bipyridine (dmobpy) yielded the nitrido-bridged dinuclear complexes [RuN(L)Cl(DMF)] where L = bpy (1), dmbpy (2), and dmobpy (3). The crystal structures of these complexes reveal a linear Ru-N-Ru moiety with each ruthenium center bearing a bidentate diimine ligand. The complexes were further characterized by NMR, IR, and UV-vis spectroscopic methods and cyclic voltammetry.

Microsecond photocapacitance transients observed using a charged microcantilever as a gated mechanical integrator.

How light is converted to electricity in blends of organic donor and acceptor molecules is an unsettled question, partly because the spatial heterogeneity present in these blends makes them challenging to characterize. Although scanned-probe measurements have provided crucially important microscopic insights into charge generation and transport in these blends, achieving the subnanosecond time resolution needed to directly observe the fate of photogenerated charges has proven difficult. We use a charged microcantilever as a gated mechanical integrator to record photocapacitance indirectly by measuring the accumulated change in cantilever phase as a function of the time delay between precisely synchronized voltage and light pulses.

Synthetic Methods for the Preparation of a Functional Analogue of Ru360, a Potent Inhibitor of Mitochondrial Calcium Uptake.

The mixed-valent oxo-bridged ruthenium complex [(HCO)(NH)Ru(μ-O)Ru(NH)(OCH)], known as Ru360, is a selective inhibitor of mitochondrial calcium uptake. Although this compound is useful for studying the role of mitochondrial calcium in biological processes, its widespread availability is limited because of challenges in purification and characterization. Here, we describe our investigations of three different synthetic methods for the preparation of a functional analogue of this valuable compound.