Publications by authors named "Sarah N Pimple"
Curr Eye Res
November 2024
Article Synopsis
- Corneal epithelial defects heal as new cells grow from the limbus, but effective topical treatments are lacking; human breast milk (HBM) contains bioactive molecules that may aid epithelial healing, prompting this study to explore its effectiveness.
- In a mouse model, defects were created and treated with HBM, a standard ophthalmic ointment, or saline, with results analyzed at multiple time points using various methods like fluorescein, RT-qPCR, and ELISA.
- Results indicated that HBM-treated corneas showed significantly better re-epithelialization and increased cellular proliferation markers (Ki67) within 8 hours of treatment, suggesting that HBM can enhance corneal wound healing and may warrant further research on limbal
