Publications by authors named "Sarah Mohammed Saeed Alsallameh"
Malaria is a potentially fatal infective illness caused due to parasites that belong to the Plasmodium genus, which are transferred to humans with the help of the stings of affected female Anopheles mosquitoes, and it persists as a serious public wellness problem worldwide. Cordia myxa is a medicinal plant that possesses various medicinal characteristics like antimicrobial, anti-inflammation, antioxidant, and antidiabetic activities, which makes it an important natural resource for the therapy of different maladies in traditional medicine. In this investigation, a certain network pharmacology method has been utilized to identify the potent active components, possible targets as well as signaling pathways present in C.
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- Traditional cancer treatments face issues like toxicity, resistance, and high costs, prompting interest in bioactive phytochemicals that target multiple molecular pathways with less harm.
- A network pharmacology approach was employed to analyze the active constituents for liver cancer treatment, utilizing databases for target retrieval and gene expression analysis.
- Key survival-related genes (HSP90AA1, ESR1, CYP3A4, CDK1, MMP9) were identified, with four potent phytochemicals potentially influencing HSP90AA1 as a therapeutic target, supported by molecular dynamics simulation results showing stable interactions.