Estimating historical exposure to perfluoroalkyl acids in Security, Fountain, and Widefield Colorado: use of water-infrastructure blending and toxicokinetic models.

Drinking water can be a major source of poly- and perfluoroalkyl substance (PFAS) exposure for humans. The lack of historic data on PFAS drinking-water concentrations and consumption patterns are a limiting factor for developing estimates of past exposure. Here, in contribution to a community-scale PFAS health effects study near fire training facilities that contaminated a local aquifer with PFASs, we present a novel water-infrastructure, mass-balance mixing model coupled to a non-steady state, single-compartment toxicokinetic model that used Monte Carlo simulations to estimate the start of PFAS exposure in drinking water for individuals within three PFAS-impacted communities in El Paso County, Colorado.

Unsaturated PFOS and Other PFASs in Human Serum and Drinking Water from an AFFF-Impacted Community.

Understanding how exposure to aqueous film-forming foam (AFFF)-impacted drinking water translates to bioaccumulation of per- and polyfluoroalkyl substances (PFASs) is essential to assess health risks. To investigate spatial variability of PFAS exposure in communities near an AFFF source zone, blood serum was collected in 2018 from 220 adult residents of El Paso County (Colorado), as were raw water samples from several wells. C6 and C8 perfluoroalkyl sulfonates (PFSAs) were predominant in serum and water.

Commercial Heritage as Democratic Action: Historicizing the 'Save the Market' Campaigns in Bradford and Chesterfield, 1969-76.

This article argues that the traditional retail market-a ubiquitous commercial feature of British towns and cities-produced a particular strand of heritage politics in late 1960s and early 1970s Britain. In recovering the activists involved in two campaigns to 'save the market' from redevelopment-one unsuccessful campaign in Bradford and one successful campaign in Chesterfield-I make the case for thinking through local urban heritage movements in comparative terms, focusing on how place-based citizenship collided with a nascent, national 'anti-development' mood in the early 1970s. The campaigns in Bradford and Chesterfield defended the transhistorical 'publicness' of the retail market-its spatial centrality, its collective ownership, and its relief of town or city rates-as a critique of contemporary, undemocratic privatization of communal space.

Multidisciplinary approach to childhood epilepsy: exploring the scientific rationale and practical aspects of implementation.

The management of childhood epilepsy requires attention to more than seizure control because children with epilepsy often suffer from comorbidities that lead to an increased frequency of psychiatric disease, learning difficulties, and other problems of psychosocial development. These comorbidities can stem in part from the same genetic traits that determine seizure susceptibility. Thus, mutations affecting potassium, calcium, and sodium channels have been linked with epilepsy syndromes and affective and behavioral abnormalities.