Publications by authors named "Sarah M Whitmire"
Article Synopsis
- The study explored the early experiences of nusinersen, a treatment for spinal muscular atrophy (SMA), from both patient and caregiver perspectives, using a comprehensive online survey.* ! -
- Respondents generally expressed satisfaction, particularly with improvements in energy and motor function, though concerns were raised about treatment administration and insurance approval issues.* ! -
- The findings highlighted ongoing challenges in accessing treatment and the need for more therapeutic options, as significant unmet needs for SMA patients persist despite advancements.* !
Background: Amyloid-β (Aβ)-stimulated microglial inflammatory responses engage mitogen-activated protein kinase (MAPK) pathways in Alzheimer's disease (AD). Mixed-lineage kinases (MLKs) regulate upstream MAPK signaling that include p38 MAPK and c-Jun amino-terminal kinase (JNK). However, whether MLK-MAPK pathways affect Aβ-mediated neuroinflammation is unknown.
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